Background: The dopaminergic receptor genes are candidate genes for manic-depressive illness (MDI). To test this putative involvement we used a case-control study on samples from the native population of the northwest part of France.
Methods: Fifty patients for D1 and D2, 61 patients for D3, and 86-223 controls were tested.
Results: No significant association was found between allelic frequencies or genotype counts and MDI, even when the data were pooled with those from published studies.
Conclusions: Single mutations of either of the studied receptor genes are not major determinants of MDI.
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