In this paper we present a new 3D discrete dynamic surface model. The model consists of vertices and edges, which connect adjacent vertices. Basic geometry of the model surface is generated by triangle patches. The model deforms by internal and external forces. Internal forces are obtained from local geometry of the model and are related to the local curvature of the surface. External forces, on the other hand, are based on the image data and are calculated from desired image features. We also present a method for generating an initial volume for the model from a stack of initial contours, drawn by the user on cross sections of the volumetric data.
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http://dx.doi.org/10.1016/s0010-4825(98)00007-9 | DOI Listing |
Background: Antibody-drug conjugate (ADC) is an anticancer drug that links toxins to specifically targeted antibodies via linkers, offering the advantages of high target specificity and high cytotoxicity. However, complexity of its structural composition poses a greater difficulty for drug design studies.
Objectives: Pharmacokinetic/pharmacodynamic (PK/PD) based consideration of ADCs has increasingly become a hot research topic for optimal drug design in recent years, providing possible ideas for obtaining ADCs with desirable properties.
In much of the northern Great Basin of the western United States, rangelands, and semi-arid ecosystems invaded by exotic annual grasses such as cheatgrass () and medusahead () are experiencing an increasingly short fire cycle, which is compounding and persistent. Improving and expanding ground-based field methods for measuring the above-ground biomass (AGB) may enable more sample collections across a landscape and over succession regimes and better harmonize with other remote sensing techniques. Developments and increased adoption of unoccupied aerial systems (UAS) and instrumentation for vegetation monitoring enable greater understanding of vegetation in many ecosystems.
View Article and Find Full Text PDFNanoscale Adv
December 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University Taif 21944 Saudi Arabia.
Mesoporous materials have garnered significant interest because of their porous structure, large surface area and ease of surface functionalization to incorporate the functional groups of choice. Herein, chiral mesoporous silica nanoparticles (CMSNPs) were prepared using quaternary amino silane as the template, tetramethyl orthosilicate as the silica source and proline and cellulose as chiral selector. The developed CMSNPs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), elemental analysis, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction analysis, BET surface area analysis and BJH pore size/volume analysis.
View Article and Find Full Text PDFJ Tradit Complement Med
November 2024
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese, Harbin, 150040, China.
Background And Aim: Goupi Plaster (GP) is topical traditional Chinese medicine preparation. It has been used to treat Knee Osteoarthritis (KOA) in clinical practice of traditional Chinese medicine (TCM). However, the mechanisms of GP relieve KOA are poorly understood.
View Article and Find Full Text PDFBiofilm
June 2025
DTU Bioengineering, Technical University of Denmark, 2800, Kongens Lyngby, Denmark.
Surfactin is a biosurfactant produced by many strains with a wide variety of functions from lowering surface tension to allowing motility of bacterial swarms, acting as a signaling molecule, and even exhibiting antimicrobial activities. However, the impact of surfactin during biofilm formation has been debated with variable findings between studies depending on the experimental conditions. B.
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