From the roots of Leuzea carthamoides, (E)-3,3'-dimethoxy-4, 4'-dihydroxystilbene (1) has been isolated and its structure elucidated by means of NMR spectroscopy, including HMQC and HMBC measurements, mass spectrometry, and X-ray crystallography.
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http://dx.doi.org/10.1021/np980128i | DOI Listing |
Int J Mol Sci
November 2022
Department of Pharmacognosy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
(Willd.) Iljin is a rare, pharmacopoeial, and medicinal plant, endemic to Siberia and endangered due to the massive collection of raw material from the natural habitat. The aim of the current study was to estimate the effect of sucrose concentration (0-7%) on transformed root growth and on caffeoylquinic acid derivative (CQA) and flavonoid production.
View Article and Find Full Text PDFOxid Med Cell Longev
March 2019
Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
(Willd.) Iljin. is an endemic plant species, which is important in Siberian medicine.
View Article and Find Full Text PDFJ Sep Sci
December 2018
Department of Chemical and Process Engineering, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, Poland.
The review presents general principles for choosing optimal conditions for ecdysteroid separation, identification, and isolation using HPLC/TLC techniques in RP, NP-HILIC or NP modes. Analytics of ecdyteroids pose a still insufficiently resolved problem. Plant-derived ecdysteroids are a point of interest of pharmaceutical industry and sport medicine due to their postulated adaptogenic and anabolic properties.
View Article and Find Full Text PDFMol Cell Biochem
August 2018
Department of Biology and Pharmaceutical Botany, Medical University of Łódź, Muszyńskiego 1, 90-151, Łódź, Poland.
The present study is the first investigation of the inhibitory effect of Rhaponticum carthamoides transformed roots (TR) extract on the proliferation of grade II and III human glioma cells. TR extract showed the cytotoxic effect and inhibited the colony formation of both glioma cell lines in dose-dependent manner. The root extract induced apoptosis by increasing of the reactive oxygen species (about threefold compared to the control cells) leading to a disruption of mitochondrial membrane potential.
View Article and Find Full Text PDFFitoterapia
June 2017
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address:
Glutamate-induced excitotoxicity is a key pathological mechanism in many neurological disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) have been shown to alleviate glutamate-induced neuronal damage; although their mechanism of action is unclear, some data suggest that they enhance signaling in the mechanistic target of rapamycin (mTOR) signaling pathway.
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