By the halothane test we determined the development of the syndrome of malignant hyperthermia in pigs of the Belgian Landrace breed with body weight of 20 kg. We found that from 27 animals that were subjected to the test 12 positively reacted to Narcotan - Spofa anaesthesis. Pigs with the syndrome of malignant hyperthermia had considerably higher rectal temperature after anaesthesis, lower PH of venose blood, higher concentration of lactic acid and glucosis in the blood plasma. Halothane-negative animals did not produce and conspicuous changes of these indices. Most differences were statisticaly highly significant.

Download full-text PDF

Source

Publication Analysis

Top Keywords

halothane test
8
syndrome malignant
8
malignant hyperthermia
8
[utilization halothane
4
test detection
4
detection malignant
4
malignant hypertension
4
hypertension syndrome
4
syndrome [mhs]
4
[mhs] pigs]
4

Similar Publications

Malignant hyperthermia (MH) is a potentially fatal disorder triggered by volatile anesthetics or succinylcholine, inducing a hypermetabolic crisis in susceptible patients. The caffeine-halothane contracture test (CHCT) remains a gold standard for MH detection. The authors describe a pregnant patient with a history of exertional rhabdomyolysis, who required urgent MH screening for administration of MH-triggering anesthetics.

View Article and Find Full Text PDF

Background: Jenacid Herbal Product (JHP) used for treating peptic ulcer disease in Uganda, sold over the counter, is approved by the National Drug Authority as a Traditional Herbal Product number THP 482. There have been no published studies on its safety and efficacy.

Objective: This study aimed to assess potential acute and subacute toxicity as well as the efficacy of JHP.

View Article and Find Full Text PDF

Tenofovir alafenamide compared to tenofovir disoproxil fumarate, induces dysglycemia, and dyslipidemia in Wistar rats.

AIDS

November 2024

Molecular and Clinical Pharmacology Research Laboratory, Department of Pharmacology, Discipline of Pharmaceutical Sciences, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

Objectives: To determine the metabolic effects of tenofovir alafenamide (TAF) compared to tenofovir disoproxil fumarate (TDF) in vivo .

Design And Methods: Male Wistar rats ( Rattus novergicus , 250-300 g body weight) were divided into three groups ( n  = 8) and orally treated daily with 1.0 ml distilled water (group 1), TAF (0.

View Article and Find Full Text PDF

Introduction: Malignant hyperthermia (MH) is a potentially life-threatening pharmacogenetic syndrome triggered by volatile anaesthetics, succinylcholine, and stress such as vigorous exercise.

Case Presentation: The authors describe a case of an 8-year-old male who presented with classical symptoms of MH after induction of general anaesthesia and symptomatic treatment was done successfully due to the unavailability of Dantrolene.

Discussion: Definitive diagnosis of MH can be done based on a contracture test in fresh muscle biopsy in the presence of halothane and caffeine.

View Article and Find Full Text PDF
Article Synopsis
  • Prolonged use of Highly Active Antiretroviral Therapy (HAART) can cause liver toxicity, with limited treatment options for hepatic cell regeneration.
  • A study assessed the protective effects of Methanol fruit extract (MFEPG) on rats undergoing HAART, revealing that MFEPG helped restore normal liver function and reduced oxidative damage indicators.
  • The findings suggest that MFEPG has antioxidant properties capable of mitigating HAART-induced liver injury, but further research is necessary to confirm its safety and efficacy.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!