Very early in the study of the mechanism of neuromuscular transmission in skeletal muscles, it was clear that the hydrolysis of acetylcholine by muscle cholinesterases within the time of the refractory period required a very high concentration of the enzyme near the motor terminals. David Nachmansohn and George B. Koelle and their collaborators obtained the first biochemical and histochemical data consistent with this prediction. Now that the various molecular forms of AChE have been satisfactorily described, it is possible to analyse the mechanisms by which they are anchored to the structures of the neuromuscular junction, and in particular, to the synaptic basal lamina.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0928-4257(98)80139-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Early phosphate changes as potential indicator of unreadiness for artificial feeding: a secondary analysis of the EPaNIC RCT.
Crit Care
January 2025
Clinical Division and Laboratory of Intensive Care Medicine, Department of Cellular and Molecular Medicine, KU Leuven, 3000, Leuven, Belgium.
Background: As compared to withholding parenteral nutrition (PN) until one week after intensive care unit (ICU) admission, Early PN prolonged ICU dependency in the EPaNIC randomized controlled trial (RCT). The Refeeding RCT showed improved outcome by temporary macronutrient restriction in ICU patients developing refeeding hypophosphatemia, defined as a phosphate decrease of > 0.16 mmol/L to levels < 0.
View Article and Find Full Text PDFAbnormal characteristics of inferior vena cava and abdominal aorta among neonates with early onset septic shock.
Ital J Pediatr
January 2025
Department of Neonatology, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao tong University, Shanghai, China.
Background: The variety of shocks in neonates, if not recognized and treated immediately, is a major cause for fatality. The use of echocardiography may improve assessment and treatment, but its reference values across gestational age (GA) and birth weight (BW) are lacking. To address the information gap, this study aimed at correlating GA and BW of newborns with nonhemodynamic abnormalities, and at evaluating the usefulness of such reference values in neonates with early onset septic (EOS) -shock.
View Article and Find Full Text PDFEarly antibiotics administration reduces mortality in sepsis patients in tertiary care hospital.
BMC Infect Dis
January 2025
Princess Srisavangavadhana College of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.
Introduction: Early antibiotic administration is one of the core treatments of sepsis which associated with reduced mortality rate. However, the appropriate timing of antibiotics remains a controversial issue, especially in patients without septic shock. Here, we reported the outcomes of early antibiotic administration within one hour from the time of infection suspicion in a tertiary care hospital.
View Article and Find Full Text PDFVery Early Health Technology Assessment for Potential Predictive Biomarkers in the Treatment of Advanced Non-Small Cell Lung Cancer.
Pharmacoecon Open
January 2025
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Objectives: Immune checkpoint inhibitor (ICI)-containing treatment is currently prescribed as first-line treatment for all patients with advanced non-small cell lung cancer (NSCLC) without targetable driver mutations. However, only 30-45% of patients show no progression within 12 months after treatment start. Various biomarkers are being studied to save costly and potentially harmful treatment in non-responders.
View Article and Find Full Text PDFEarly osteopathic manipulative treatment to prevent cranial positional deformities: A randomized controlled trial.
Arch Pediatr
January 2025
Pediatric Orthopedic and Plastic Surgery, University of Montpellier, Montpellier University Hospital, Montpellier, France; Centre de Compétence Maladies Rares CRANIOST, University of Montpellier, Montpellier University Hospital, Montpellier, France. Electronic address:
Background: Cranial positional deformities occur frequently in the first months of life.
Objective: To evaluate the effectiveness of osteopathic manipulative treatment (OMT) in preventing the onset of positional plagiocephaly and brachycephaly at 4 months in at-risk newborns.
Methods: This single-center, randomized, controlled open-label study, with blinded assessment of the endpoints, was carried out at the maternity unit of Montpellier University Hospital (France) between 2019 and 2022.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!