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Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice.
Biochemistry (Mosc)
February 2024
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, SE-106 91, Sweden.
An increase in mitochondrial DNA (mtDNA) mutations and an ensuing increase in mitochondrial reactive oxygen species (ROS) production have been suggested to be a cause of the aging process ("the mitochondrial hypothesis of aging"). In agreement with this, mtDNA-mutator mice accumulate a large amount of mtDNA mutations, giving rise to defective mitochondria and an accelerated aging phenotype. However, incongruously, the rates of ROS production in mtDNA mutator mitochondria have generally earlier been reported to be lower - not higher - than in wildtype, thus apparently invalidating the "mitochondrial hypothesis of aging".
View Article and Find Full Text PDF[Contribution of Academician M.M. Krasnov to ophthalmological science and practice].
Vestn Oftalmol
May 2023
International Academy of Business and Management, Moscow, Russia.
The scientific legacy of Professor Mikhail Mikhailovich Krasnov, Academician of the Russian Academy of Medical Sciences, is large and multifaceted. His name is associated with the whole epoch of establishment and development of new methods of diagnostics and treatment of eye diseases. The representative of the dynasty of ophthalmologists M.
View Article and Find Full Text PDFThe Validation of Cardiac Index and Stroke-Volume Variation Measured by the Pulse-Wave Transit Time-Analysis Versus Conventional Pulse-Contour Analysis After Off-Pump Coronary Artery Bypass Grafting: Observational Study.
J Cardiothorac Vasc Anesth
June 2023
Department of Anesthesiology and Intensive Care Medicine, Northern State Medical University, Arkhangelsk, Russia; Department of Anesthesiology and Intensive Care Medicine, City Hospital #1 n.a. E.E. Volosevich, Arkhangelsk, Russia.
Objective: To compare the reliability of cardiac index (CI) and stroke-volume variation (SVV) measured by the pulse-wave transit-time (PWTT) method using estimated continuous cardiac output (esCCO) technique with conventional pulse-contour analysis after off-pump coronary artery bypass grafting (OPCAB).
Design: A single-center, prospective, observational study.
Setting: At a 1,000-bed university hospital.
At the section "Fundamentals of photodynamic, laser and PUVA therapy," 32 reports were presented in full-time and on-line format. Representatives of various scientific schools reported on the results of fundamental and applied research on the processes occurring at the cellular and organismal levels upon irradiation with low-intensity red light and upon the introduction of photosensitizers of various nature, followed by laser irradiation. Scientific reports proposed new photosensitizers, as well as their conjugates with biologically active molecules for fluorescent diagnostics and photodynamic therapy of oncological diseases.
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