AI Article Synopsis
- - The nucleotide sequence of the dengue-1 virus strain from 1974 (West Pac 74) has been fully determined, measuring 10,735 nucleotides in length.
- - This genome features a long open reading frame that encodes a polyprotein consisting of 3,392 amino acids.
- - When compared to another strain (DEN-1 Singapore S275/90), there is a high level of sequence similarity, with 94% nucleotide and 97.8% amino acid homology.
Article Abstract
We have determined the complete nucleotide sequence and the deduced amino acid polypeptide sequence of the genome of a dengue-1 (DEN-1) virus strain isolated from a patient on Nauru in the Western Pacific in 1974 (West Pac 74). The complete genome is 10,735 nucleotides in length and contains a single long open reading frame of 10,176 nucleotides encoding a polyprotein of 3392 amino acids. When compared to DEN-1 Singapore S275/90, the nucleotide and amino acid sequence homology are 94% and 97.8%, respectively.
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| http://dx.doi.org/10.1023/a:1008009202695 | DOI Listing |
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