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Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control.
J Immunother Cancer
October 2024
Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Background: Immune checkpoint blockade (ICB) therapies are an important treatment for patients with advanced cancers; however, only a subset of patients with certain types of cancer achieve durable remission. Cancer vaccines are an attractive strategy to boost patient immune responses, but less is known about whether and how immunization can induce long-term tumor immune reprogramming and arrest cancer progression. We developed a clinically relevant genetic cancer mouse model in which hepatocytes sporadically undergo oncogenic transformation.
View Article and Find Full Text PDFDevelopment of a + Cardiac Mouse Progenitor Immortalized Model to Unravel the Relationship with Its Protective Vascular Endothelial Niche.
Int J Mol Sci
August 2024
Cardiac Stem Cells Lab, Immunology and Oncology Department, National Center for Biotechnology (CNB-CSIC), Campus Universidad Autónoma de Madrid, 28049 Madrid, Spain.
The adult mammalian heart has been demonstrated to be endowed with low but real turnover capacity, especially for cardiomyocytes, the key functional cell type. The source, however, of that turnover capacity remains controversial. In this regard, we have defined and characterized a resident multipotent cardiac mouse progenitor population, +DR (for + Damage-Responsive cells).
View Article and Find Full Text PDFDevelopment and Characterization of Syngeneic Orthotopic Transplant Models of Obesity-Responsive Triple-Negative Breast Cancer in C57BL/6J Mice.
Cancers (Basel)
August 2024
Department of Nutrition, University of North Carolina, Chapel Hill, NC 27599, USA.
Obesity is an established risk and progression factor for triple-negative breast cancer (TNBC), but preclinical studies to delineate the mechanisms underlying the obesity-TNBC link as well as strategies to break that link are constrained by the lack of tumor models syngeneic to obesity-prone mouse strains. C3(1)/SV40 T-antigen (C3-TAg) transgenic mice on an FVB genetic background develop tumors with molecular and pathologic features that closely resemble human TNBC, but FVB mice are resistant to diet-induced obesity (DIO). Herein, we sought to develop transplantable C3-TAg cell lines syngeneic to C57BL/6 mice, an inbred mouse strain that is sensitive to DIO.
View Article and Find Full Text PDF[3-Methyladenine alleviates early renal injury in diabetic mice by inhibiting AKT signaling].
Nan Fang Yi Ke Da Xue Xue Bao
July 2024
Department of Immunology, Medical College of Yangtze University, Jingzhou 434023, China.
Objective: To explore the mechanism of 3-methyladenine (3-MA) for alleviating early diabetic renal injury.
Methods: Mouse models of streptozotocin (STZ) -induced diabetes mellitus were randomized into model group and 3-MA treatment group for daily treatments with normal saline and 10 mg/kg 3-MA by gavage for 6 weeks, respectively. Body weight and fasting blood glucose of the mice were recorded every week.
Case-control study: Unveiling human polyomaviruses and papillomavirus in Egyptian colorectal cancer patients.
PLoS One
June 2024
Biochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.
Background: Colorectal cancer (CRC) is a cancer type that is thought to be influenced by human papillomaviruses (HPVs) and human polyomaviruses (HPyVs). In Egypt, CRC ranks as the 7th most common cancer, accounting for 3.47% of male cancers and 3% of female cancers.
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