Introduction: Geotrichum capitatum sepsis are rare, occurring exclusively in immunocompromised patients.
Exegesis: We report the case of a patient with acute leukemia, presenting with chemotherapy-induced neutropenia and hospitalized in an intensive care unit for a severe sepsis. In spite of an antibiotic and antifungal treatment, the patient died of cardiorespiratory failure. Later on, blood cultures proved to be positive for Geotrichum capitatum.
Conclusion: If fungal infections are common in neutropenic patients, Geotrichum capitatum sepsis remain exceptional. The portal of entry is digestive or respiratory, and the invasion is favored by immunodepression and suppression of the normal microbial flora. Induced lesions can be multiorganic. The treatment is not well established, and the association of either amphotericine B and 5-fluorocytosine or amphotericine B and itraconazole would lead to better results. Nevertheless, the prognosis is still unfavorable, with a mortality rate of approximately 75%.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0248-8663(98)80868-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnusiomyces capitatus, an Unusual Cause of Invasive Fungal Infections in Neutropenic Patients: Case Reports and Outbreak Investigation.
Mycopathologia
January 2025
Department of Clinical Microbiology, St. James Hospital, Dublin, Ireland.
Magnusiomyces capitatus is an environmental fungus found in soil, water, air, plants, and dairy products which may cause opportunistic infections in patients with haematological disorders resulting in high mortality rates. This series of the first reported cases in Ireland discusses investigation of two patients with underlying haematological disorders, hospitalised in the Irish National Adult Stem Cell Transplant Unit (NASCTU), who developed line-related fungaemias with M. capitatus within a three-month period.
View Article and Find Full Text PDFMycotic aneurysm due to Magnusiomyces capitatus complicating a second liver transplant in a colonized patient.
Int J Infect Dis
December 2024
Institut des Agents Infectieux, Laboratoire de Parasitologie et Mycologie Médicale, Hospices Civils de Lyon, Lyon, France; UR 3738-CICLY-Equipe Inflammation et Immunité de L'épithélium Respiratoire, Faculté de Médecine Lyon-Sud Charles Mérieux, Université Claude Bernard Lyon 1, Lyon, France. Electronic address:
This report presents an extremely rare case of a fungal mycotic aneurysm due to Magnusiomyces capitatus in a 51-year-old woman who is immunocompromised. The diagnosis was based on multiple computed tomography scans and the identification of the pathogen via sequencing of the internal transcribed spacer region. Long-term treatment with caspofungin for previous candidemia likely promoted the dissemination of this intrinsically echinocandin-resistant fungus from colonization sites in the lungs and rectal area.
View Article and Find Full Text PDFA comprehensive study on the autochthonous microbiota, volatilome, physico-chemical, and morpho-textural features of Montenegrin Njeguški cheese.
Food Res Int
December 2024
Dipartimento di Scienze Agrarie, Alimentari ed Ambientali, Università Politecnica delle Marche, Brecce Bianche, 60131 Ancona, Italy.
The present study aims to deepen the knowledge of the microbiota, gross composition, physico-chemical and morpho-textural features, biogenic amines content and volatilome of Njeguški cheese, one of the most popular indigenous cheeses produced in Montenegro. Cheese samples were collected in duplicate from three different batches produced by three Montenegrin artisan producers. For the first time, the microbiota of Njeguški cheese was investigated using both culture-dependent techniques and metagenomic analysis.
View Article and Find Full Text PDFSuccessful management with urgent haploidentical-peripheral blood stem cell transplantation for a patient with severe aplastic anaemia who developed disseminated fungal infection following immunosuppressive therapy.
EJHaem
October 2024
Children's Cancer Center National Center for Child Health and Development Tokyo Japan.
Article Synopsis
- * It highlights the complexities of performing allogeneic transplants amid active infections, as they typically have poor outcomes.
- * A specific case is presented about a 5-year-old boy with disseminated infection who received granulocyte transfusions from his mother and underwent successful haploidentical stem cell transplantation from his father after immunosuppressive treatment for SAA.
A Case of Pulmonary Infection Due to in a Non-Immunocompromised Patient with Cerebral Palsy.
Infect Drug Resist
October 2024
Department of Emergency Medicine, Tongxiang First People's Hospital, Jiaxing, Zhejiang, People's Republic of China.
Background: () is a dimorphic opportunistic fungus that is a rare yeast and rarely reported in Asia. Owing to the absence of established clinical breakpoints, the treatment of this fungus poses challenges.
Case Presentation: We report a rare case of a young, non-immunocompromised man with cerebral palsy, spinal deformity, and pulmonary infection.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!