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C5aR1-positive adipocytes mediate non-shivering thermogenesis in neonatal mice.
iScience
December 2024
Research Group of Endocrinology & Metabolism, Key Laboratory of Vascular Aging, Ministry of Education, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Brown adipose tissue (BAT) plays an important role in maintaining body temperature in newborn mammals; however, its mechanisms remain poorly understood. Here, we report the identification of a special population of brown adipose tissue-derived stromal cells (ASCs) in neonatal mice that highly express CD45 and can be differentiated into adipocytes with lower thermogenic ability. These CD45 adipocytes also characteristically contained complement C5a receptor 1(C5aR1) on the cell membrane.
View Article and Find Full Text PDFThe early transition to cold-induced browning in mouse subcutaneous white adipose tissue (scWAT) involves proteins related to nerve remodeling, cytoskeleton, mitochondria, and immune cells.
Adipocyte
December 2024
Department of Neurological Surgery, The Ohio State University, Columbus, OH, USA.
White adipose tissue (WAT) is a dynamic organ capable of remodelling in response to metabolic state. For example, in response to stimuli such as cold exposure, WAT can develop inducible brown adipocytes ('browning') capable of non-shivering thermogenesis, through concurrent changes to mitochondrial content and function. This is aided by increased neurite outgrowth and angiogenesis across the tissue, providing the needed neurovascular supply for uncoupling protein 1 activation.
View Article and Find Full Text PDFHyperactive browning and hypermetabolism: potentially dangerous element in critical illness.
Front Endocrinol (Lausanne)
December 2024
Department of Basic Medical Sciences, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Article Synopsis
- - Brown/beige adipose tissue is known for enhancing metabolism and fighting obesity through a process called non-shivering thermogenesis, which has been the focus of much research.
- - Recent studies highlight that during critical illness, excessive activation of brown fat or the conversion of white fat to brown fat can lead to harmful effects by worsening hypermetabolism.
- - This review will explore the implications of fat browning in critical illness, including its potential risks, regulatory mechanisms, and clinical treatment options, aiming to deepen understanding and inspire new treatments for patients in hypermetabolic states.
Body size influences the capacity to cope with extreme cold or hot temperatures in the striped hamster.
J Therm Biol
December 2024
College of Life and Environmental Science, Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection, Wenzhou University, Wenzhou, 325035, China. Electronic address:
Body size of organisms is a key trait influencing nearly all aspects of their life history. Despite growing evidence of Bergmann's rule, there is considerably less known about the links between body size and the maximum capacity to thermoregulate of an animal in response to extreme cold or hot environment. Thermal characteristics such as resting metabolic rate (RMR) and non-shivering thermogenesis (NST), and the upper- and lower-critical temperatures of the thermal neutral zone (TNZ) were investigated in small and large body sized striped hamsters (Cricetulus barabensis).
View Article and Find Full Text PDFDietary Intake Is Similar Among Adult Men with Different Levels of Cold-Induced Brown Adipose Tissue Activation.
Nutrients
October 2024
FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece.
Background/objectives: Brown adipose tissue (BAT) activation has important metabolic health implications, yet the relationship between habitual dietary intake and BAT activity in humans remains to be fully understood.
Methods: We compared dietary intake among adult men with (BAT, age: 34.8 ± 5.
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