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Biological effects of inhaled 239PuO2 in Beagles.
Radiat Res
November 2012
Washington State University-Tri-Cities, Richland, Washington, USA.
Seven groups of 8-24 Beagle dogs, exposed to (239)PuO(2) aerosols by inhalation [mean initial lung depositions (ILD) of 0.0, 0.14, 0.
View Article and Find Full Text PDFCarcinogenesis from inhaled (239)PuO(2) in beagles: Evidence for radiation homeostasis at low doses?
Health Phys
September 2010
Isotope Sciences Program, Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, WA 99354, USA.
From the early 1970's to the late 1980's, Pacific Northwest National Laboratory conducted life-span studies in beagle dogs on the biological effects of inhaled plutonium ((238)PuO(2), (239)PuO(2), and Pu[NO(3)](4)) to help predict risks associated with accidental intakes in workers. Years later, the purpose of the present follow-up study was to reassess the dose-response relationship for lung cancer in the PuO(2) dogs compared to controls-with particular focus on the dose-response at relatively low lung doses. A PuO(2) aerosol (2.
View Article and Find Full Text PDFCarcinogenic interactions between a single inhalation of 239PuO2 and chronic exposure to cigarette smoke in rats.
Radiat Res
May 2010
Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA.
Rats were exposed once by inhalation to plutonium-239 dioxide ((239)PuO(2)), resulting in chronic alpha-particle irradiation of the lung, and exposed chronically to cigarette smoke to examine carcinogenic interactions between the two exposures. F344 rats were exposed to (239)PuO(2) to achieve an initial lung burden of 0.5 kBq and then exposed 6 h/day, 5 days/week to cigarette smoke at 100 or 250 mg particulate matter/m(3) for up to 30 months.
View Article and Find Full Text PDFRadiotoxicity of inhaled (239)PuO(2) in dogs.
Radiat Res
December 2008
Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA.
Beagle dogs inhaled graded exposure levels of insoluble plutonium dioxide ((239)PuO(2)) aerosols in one of three monodisperse particle sizes at the Lovelace Respiratory Research Institute (LRRI) to study the life-span health effects of different degrees of alpha-particle dose non-uniformity in the lung. The primary noncarcinogenic effects seen were lymphopenia, atrophy and fibrosis of the thoracic lymph nodes, and radiation pneumonitis and pulmonary fibrosis. Radiation pneumonitis/ pulmonary fibrosis occurred from 105 days to more than 11 years after exposure, with the lowest associated alpha-particle dose being 5.
View Article and Find Full Text PDFThe distribution of the number of alpha hits per target cell: a new parameter to improve risk assessment for cancer induction using ICRP models.
Radiat Prot Dosimetry
August 2008
Laboratoire de Radiotoxicologie, SRCA/DRR/DSV/CEA, BP 12, 91680 Bruyères le Châtel, France.
Doses are calculated from the total energy deposited within the different target regions of the organism. After inhalation exposure, only a few particles can be deposited within the respiratory tract that induces a heterogeneous dose distribution. A decrease in risk for lung tumours induction associated to the presence of hot spots has been reported.
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