The authors report a case of isolated thrombus of the aortic arch discovered incidentally during thoracic CT angiography, complicated by clinical features of embolic renal infarction despite introduction of anticoagulant treatment. This case confirms the value of transoesophageal echocardiography to diagnose and follow these lesions and illustrates the therapeutic approach following discovery of aortic thrombi.
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Early Radiographic Warning Signs of Impending Lemierre's Syndrome.
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Otolaryngology - Head and Neck Surgery, Albany Medical Center, Albany, USA.
Lemierre's syndrome is a rare and potentially life-threatening complication of head and neck infections, such as bacterial pharyngitis or tonsillitis. It is characterized by the extension of infection into the lateral pharyngeal spaces, leading to subsequent septic thrombophlebitis of the internal jugular vein(s). Although relatively uncommon since the advent of appropriate antibiotic therapy, the incidence of Lemierre's syndrome has increased in the past 15 years, especially among young, healthy adults.
View Article and Find Full Text PDFLiving Donor Liver Transplantation for Young Biliary Atresia Recipients Is Associated With Improved Outcomes in the Modern Era.
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Department of Pediatrics, Pediatric Liver Center, Digestive Health Institute and Section of Pediatric Gastroenterology, Hepatology & Nutrition, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
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Modelling blood flow in the circle of Willis in continuous flow left ventricular assist devices: possible relevance to strokes.
Indian J Thorac Cardiovasc Surg
February 2025
Department of Engineering Design, Indian Institute of Technology Madras, Chennai, India.
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Department of Cardiovascular & Thoracic Surgery, Seth GS Medical College & KEM Hospital, Mumbai, Maharashtra India.
The subclavian artery's intrathoracic segment is a rare peripheral artery aneurysm site. Common causes are atherosclerosis, trauma, vasculitis, and infection. Subclavian artery aneurysms have a higher propensity for rupture, thrombosis, embolization, and compression of surrounding structures, thus necessitating urgent surgical care.
View Article and Find Full Text PDFAssays of Platelet SNARE-actin Interactions.
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January 2025
Division of Hemostasis and Thrombosis, Department of Medicine, BIDMC, Harvard Medical School, Boston, MA, USA.
The actin cytoskeleton serves an important, but poorly characterized, role in controlling granule exocytosis. The dynamic nature of actin remodeling allows it to act both as a barrier to prevent indiscriminate granule release and as a facilitator of membrane fusion. In its capacity to promote exocytosis, filamentous actin binds to components of the exocytotic machinery through actin binding proteins, but also through direct interactions with SNAREs.
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