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Lateral olivocochlear neurons modulate cochlear responses to noise exposure.
Proc Natl Acad Sci U S A
January 2025
Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including loud, damage-inducing sounds. In response to internal and external stimuli, the central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), which are located in the brainstem and innervate the cochlear sensory epithelium.
View Article and Find Full Text PDFTargeting breast cancer stem cells in ER-positive breast cancer by repurposing the benzoporphyrin derivative verteporfin as a YAP/TAZ small molecule inhibitor.
Mol Biol Rep
January 2025
Cancer Research Laboratory, Department of Zoology, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal, 700019, India.
Background: Current treatment strategies for hormone-dependent breast cancers, including adjuvant endocrine therapy, often fail due to persistence of breast cancer stem cells (brCSCs), which are significant contributors to tumor recurrence and treatment resistance. Therefore, gaining deeper insights into the molecular regulators driving breast cancer aggressiveness is important. Moreover, given the complexities and expenses involved in developing new pharmacological agents, the strategic repurposing of existing FDA-approved drugs to target these key molecular pathways presents a compelling approach for identifying novel therapeutic interventions aimed at mitigating tumor refractoriness.
View Article and Find Full Text PDFTransperineal MR Fusion Laser Ablation of Prostate Cancer in Office Setting: 1 Year Efficacy and Safety Outcomes in Intermediate-Risk Patients.
J Endourol
January 2025
Urological Research Network, Miami Lakes, Florida, USA.
Focal therapy (FT) is an emerging option for intermediate-risk prostate cancer (IR-PCa). Transperineal MRI fusion laser ablation of PCa (TPFLA) is a novel FT technique with limited data reported. We conducted a phase I clinical trial evaluating the safety, feasibility, and 1-year oncologic results for patients with IR-PCa treated with TPFLA in an office setting.
View Article and Find Full Text PDFEvaluation of Local Tumor Outcomes Following Microwave Ablation of Colorectal Liver Metastases Using CT Imaging: A Comparison of Visual versus Quantitative Methods.
Radiol Imaging Cancer
January 2025
From the Department of Radiology, Royal Marsden Hospital NHS Foundation Trust, 203 Fulham Road, London SW3 6JJ, England (J.D.S., L.K., L.P., J.M., N.K., D.M.K., E.J.); Institute of Cancer Research, London, England (N.P., D.M.K.); and Department of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, the Netherlands (W.O.).
Purpose To compare visual versus quantitative ablation confirmation for identifying local tumor progression and residual tumor following microwave ablation (MWA) of colorectal liver metastases (CRLM). Materials and Methods This retrospective study included patients undergoing MWA of CRLM from October 2014 to February 2018. Two independent readers visually assessed pre- and postprocedure images and semiquantitatively scored for incomplete ablation, using a six-point Likert scale, and extracted quantitative imaging metrics of minimal ablative margin (MAM) and percentage of tumor outside of the ablation zone, using both rigid and deformable registration.
View Article and Find Full Text PDFMoS-Plasmonic Hybrid Platforms: Next-Generation Tools for Biological Applications.
Nanomaterials (Basel)
January 2025
Department of Applied Chemistry and Institute of Natural Sciences, Kyung Hee University, Yongin-si 17104, Gyeonggi-do, Republic of Korea.
The combination of molybdenum disulfide (MoS) with plasmonic nanomaterials has opened up new possibilities in biological applications by combining MoS's biocompatibility and high surface area with the optical sensitivity of plasmonic metals. These MoS-plasmonic hybrid systems hold great promise in areas such as biosensing, bioimaging, and phototherapy, where their complementary properties facilitate improved detection, real-time visualization, and targeted therapeutic interventions. MoS's adjustable optical features, combined with the plasmon resonance of noble metals such as gold and silver, enhance signal amplification, enabling detailed imaging and selective photothermal or photodynamic therapies while minimizing effects on healthy tissue.
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