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Evaluating Spironolactone Monotherapy Against Combined Treatment with Metformin in Rat PCOS Model.
Eur J Pharmacol
March 2025
Department of Biological Sciences, Khalifa University, Abu Dhabi, P.O 127788, United Arab Emirates; Center for Biotechnology, Khalifa University, Abu Dhabi, P.O 127788, United Arab Emirates. Electronic address:
Polycystic ovarian syndrome (PCOS) is a common gynecological disorder with multifactorial pathogenic risk factors. Combination therapy with metformin and thiazolidinedione derivatives is frequently used, but its synergistic effects have not been thoroughly evaluated. This study aims to compare the therapeutic efficacy of low-dose spironolactone (LDS) at 0.
View Article and Find Full Text PDFBackground: Functional hypothalamic amenorrhea (FHA) and polycystic ovary syndrome (PCOS) are pathologies most common in women of reproductive age. Menstrual irregularities (oligo/amenorrhea) are the most common symptom of these diseases. FHA develops against the background of stress or excessive physical exertion, and is characterized by inhibition of neuroendocrine regulation of the hypothalamic-pituitary-ovarian axis with a subsequent decrease in the production of sex steroids.
View Article and Find Full Text PDFUltrastructure assessment of oocyte from mouse with polycystic ovary syndrome following cryopreservation.
Cryo Letters
March 2025
Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
Background: The polycystic ovary syndrome (PCOS) is a substantial obstacle to female fertility due to ovulation inhibition. Oocyte cryopreservation is crucial for preserving fertility in women with fertility-compromising disorders such as PCOS.
Objective: In this study, the ultrastructural damages of oocytes were evaluated following freezing from PCOS mouse model.
Impact of enhanced recovery after surgery concept process optimization on the perioperative period of gynecologic laparoscopic surgery.
BMC Womens Health
March 2025
Department of Gynecology, Jiaxing Hospital of Traditional Chinese Medicine, Zhejiang University of Traditional Chinese Medicine, Jiaxing, Zhejiang, 314000, China.
Background: To explore the impact of enhanced recovery after surgery (ERAS) optimization concept process on the perioperative period of gynecologic laparoscopic surgery.
Methods: This retrospective observational study included patients who underwent gynecologic laparoscopic surgery based on ERAS concept process optimization (ERAS group) for uterine fibroids, adenomyosis, and ovarian cysts at Jiaxing Hospital of Traditional Chinese Medicine between January 2023 and December 2023. Patients who underwent the same laparoscopic protocol without ERAS concept process optimization between January 2022 and December 2022 were matched as the control group (non-ERAS group).
Biochemical, sex hormonal, and anthropometric predictors of non-alcoholic fatty liver disease in polycystic ovary syndrome.
BMC Womens Health
March 2025
Department of Radiology, Beijing Jishuitan Hospital, Capital Medical University, Beijing, 100035, PR China.
Background: Polycystic ovary syndrome (PCOS) is linked to non-alcoholic fatty liver disease (NAFLD). Biochemical, sex hormonal, and anthropometric indicators have been explored for screening NAFLD in PCOS patients. However, the accuracy of NAFLD screening using these indicators in PCOS patients remains uncertain.
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