The effect of progestins on intracellular corticosteroid-binding globulin (CBG) mRNA expression in an endometrial cancer cell line (Ishikawa) was examined in an attempt to understand the biological effects of high-dose progestins in the treatment of well-differentiated uterine endometrial cancers. Oestradiol-17 beta (E2) significantly increased CBG mRNA expression in a dose-dependent manner, while a high dose of progesterone with or without E2 suppressed it significantly. Furthermore, a high dose of progesterone or medroxyprogesterone acetate (MPA) suppressed CBG mRNA expression to a greater degree than did chlormadinone acetate or 17 alpha-hydroxyprogesterone caproate with or without E2. These findings suggest that the effects of high-dose progestins on cancer cells may be mediated via suppression of intracellular CBG.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/000456329803500507 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-Omics Approaches Uncovered Critical mRNA-miRNA-lncRNA Networks Regulating Multiple Birth Traits in Goat Ovaries.
Int J Mol Sci
November 2024
College of Animal and Veterinary Sciences, Southwest Minzu University, Chengdu 610041, China.
The goat breeding industry on the Tibetan Plateau faces strong selection pressure to enhance fertility. Consequently, there is an urgent need to develop goat lines with higher fertility and adaptability. The ovary, as a key organ determining reproductive performance, is regulated by a complex transcriptional network involving numerous protein-coding and non-coding genes.
View Article and Find Full Text PDFAndrogens Suppress Corticosteroid Binding Globulin in Male Mice, Affecting the Endocrine Stress Response.
Endocrinology
August 2024
Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, Netherlands.
Biological sex affects the activity of the hypothalamus-pituitary-adrenal (HPA) axis. However, how androgen deprivation affects this axis remains largely unknown. In this study, we investigated the effect of androgen status on different components of the HPA axis in male mice.
View Article and Find Full Text PDFCerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity.
Sci Rep
July 2024
Department of Dental Biomaterials and Research Institute of Oral Science, College of Dentistry, Gangneung-Wonju National University, Gangneung, 25457, Republic of Korea.
45S5 Bioglass (BG) is composed of a glass network with silicate based on the component and can be doped with various therapeutic ions for the enhancement of hard tissue therapy. Nanoceria (CeO) has been shown to indicate redox reaction and enhance the biological response. However, few studies focus on the proportion of CeO-doped and its effect on the cellular bioactivity of CeO-doped BG (CBG).
View Article and Find Full Text PDFEnvironment modulates protein heterogeneity through transcriptional and translational stop codon readthrough.
Nat Commun
May 2024
Max Planck Institute of Molecular Cell Biology and Genetics, 01307, Dresden, Germany.
Stop codon readthrough events give rise to longer proteins, which may alter the protein's function, thereby generating short-lasting phenotypic variability from a single gene. In order to systematically assess the frequency and origin of stop codon readthrough events, we designed a library of reporters. We introduced premature stop codons into mScarlet, which enabled high-throughput quantification of protein synthesis termination errors in E.
View Article and Find Full Text PDFCannabidivarin and cannabigerol induce unfolded protein response and angiogenesis dysregulation in placental trophoblast HTR-8/SVneo cells.
Arch Toxicol
September 2024
Faculty of Pharmacy, Laboratory of Biochemistry, UCIBIO, Applied Molecular Biosciences Unit, University of Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313, Porto, Portugal.
Cannabidivarin (CBDV) and cannabigerol (CBG) are minor phytocannabinoids from Cannabis sativa, whose health benefits have been reported. However, studies about the impact of these cannabinoids on fundamental cellular processes in placentation are scarce. Placental development involves physiological endoplasmic reticulum (ER) stress, however when exacerbated it can lead to altered angiogenesis and pregnancy disorders, such as intrauterine growth restriction and preeclampsia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!