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Multiple Pyoderma Gangrenosum Overlying AV Fistula Treated With Colchicine: A Case Report.
Can J Kidney Health Dis
October 2024
Département de Médecine, Hôpital du Sacré-Coeur de Montréal, QC, Canada.
Article Synopsis
- - Pyoderma gangrenosum (PG) is a rare condition that causes painful ulcers, which can occur after trauma like needle insertion, a phenomenon known as pathergy; this report highlights a 69-year-old woman who developed PG after hemodialysis.
- - The patient experienced painful ulcers at the site of needle insertion on her arteriovenous fistula (AVF), prompting a diagnosis of PG following a thorough evaluation that ruled out other causes.
- - Treatment involved suspending dialysis through the AVF and using medications such as prednisone, topical corticosteroids, and colchicine to manage PG; her condition improved, allowing for safe resumption of dialysis while minimizing the risk of further complications.
Risks and benefits of anti-TNF therapy for ulcerative colitis in a patient with autoimmune hepatitis-related cirrhosis: Case report.
Medicine (Baltimore)
August 2024
Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Botucatu, Brazil.
Rationale: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) characterized by continuous inflammation of the colonic mucosa. Autoimmune hepatitis (AIH) is a chronic liver disease characterized by hypergammaglobulinemia, circulating autoantibodies, interface hepatitis, and favorable response to immunosuppression. An association between IBD and AIH is uncommon, and experts have suggested that in patients with overlapping IBD and AIH, the anti-tumor necrosis factor agents can be used.
View Article and Find Full Text PDFSerum bile acids profiles are altered without change of the gut microbiota composition following a seven-day prednisolone therapy in severe alcoholic hepatitis.
Gut Microbes
July 2024
GRAP INSERM U1247, Universite de Picardie Jules Verne, Amiens, France.
Article Synopsis
- Severe Alcoholic Hepatitis (sAH) is a liver condition resulting from long-term heavy drinking, and corticosteroids are the main treatment option.
- A study at Amiens University Hospital analyzed gut microbiota in 27 sAH patients before and after a 7-day corticosteroid treatment, finding no significant changes in microbiota composition or SCFA levels.
- While the gut microbiota remained stable, the study noted a reduction in certain bile acid ratios and LBP levels in serum, suggesting potential improvements in gut barrier function and implications for future treatments targeting gut microbiota.
[Incidence, characteristics and survival of patients with pneumocystis pneumonia in solid oncology].
Bull Cancer
September 2024
Service d'oncologie médicale, centre Eugène-Marquis, avenue de la Bataille Flandres-Dunkerque, 35042 Rennes, France.
Introduction: Pulmonary pneumocystis causes interstitial lung disease, particularly in patients with solid cancers. The aim of this study is to clarify its incidence, which remains poorly understood, and to identify patients at risk and prognostic factors.
Methods: Data on patients with solid tumors and pulmonary pneumocystis were retrospectively collected from January 1, 2014 to December 31, 2019 in two hospitals in Rennes.
LSD1 inhibition circumvents glucocorticoid-induced muscle wasting of male mice.
Nat Commun
April 2024
Université de Strasbourg, CNRS, Inserm, IGBMC UMR 7104- UMR-S 1258, F-67400, Illkirch, France.
Synthetic glucocorticoids (GC), such as dexamethasone, are extensively used to treat chronic inflammation and autoimmune disorders. However, long-term treatments are limited by various side effects, including muscle atrophy. GC activities are mediated by the glucocorticoid receptor (GR), that regulates target gene expression in various tissues in association with cell-specific co-regulators.
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