Fc-binding molecules specific for human IgG1 and IgG3 are present in Echinococcus granulosus protoscoleces.

Parasite Immunol

Cátedra de Inmunologá, Casilla de Correos 1157, Facultad de Química, Facultad de Ciencias, Montevideo, Uruguay.

Published: September 1998

In this work we describe the presence of Fc-binding activity on the suckers and tegument of E. granulosus protoscoleces. A fraction (PSA-Fc+) from protoscolex somatic antigens was isolated by affinity chromatography on human Fc-gamma1-Sepharose. Analysis by SDS-PAGE of PSA-Fc+ showed that it contained two major components. Using mouse F(ab')2-human Fc chimaeric monoclonal antibodies we verified that PSA-Fc+ bound mainly to human Fc-gamma1 and Fc-gamma3 isotypes. In addition, one of the components of PSA-Fc+ showed proteolytic activity. Both, Fc-binding and proteolytic activities localized on the protoscolex surface, may play a relevant role in the host-parasite interaction.

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http://dx.doi.org/10.1046/j.1365-3024.1998.00147.xDOI Listing

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