Development of a heterologous model in germfree suckling rats for studies of rotavirus diarrhea.

J Virol

Unité d'Ecologie et de Physiologie du Système Digestif, Equipe Métabolites Bactériens et Santé, INRA, 78352 Jouy-en-Josas Cedex, France.

Published: November 1998

Germfree suckling rats were infected with an SA11 rotavirus strain. Infected pups developed diarrhea associated with histopathological changes. The virus was detected in feces and in the small intestine. Cellular vacuolation was observed in the villi of the jejunum. These results provide a new model for further investigations of group A rotavirus infection.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC110350PMC
http://dx.doi.org/10.1128/JVI.72.11.9298-9302.1998DOI Listing

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