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Refractory drug-induced systemic small-vessel vasculitis with two varied extracutaneous manifestations: a case report and review of the literature.
J Med Case Rep
October 2023
Department of Angiology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Background: Clopidogrel and ticagrelor are rarely reported to cause vasculitis via drug hypersensitivity reaction, largely mediated by T cells and immunoglobulin E (IgE). Despite therapeutic advances, the etiology of refractory vasculitides remains incompletely understood. Recently, (non)immunological mechanisms bypassing T cells and IgE have been proposed to explain resistance to standard immunosuppressants.
View Article and Find Full Text PDFRevascularization of acute stent thrombosis caused by diarrhea after carotid artery stenting in an intermediate clopidogrel metabolizer.
BMC Neurol
July 2023
Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, Second Affiliated Hospital of Soochow University, No. 1055 Sanxiang Road, Suzhou, 215004, China.
Carotid artery stenting (CAS) is an alternative treatment to carotid endarterectomy for carotid artery stenosis. Acute stent thrombosis (ACST) is an extremely rare complication but can have devastating consequences. Although many cases have been reported, the best treatment is still uncertain.
View Article and Find Full Text PDFA Case of Lupus Enteritis in Which Multiple Colorectal Ulcers Were the Only Signs of Relapse.
Tokai J Exp Clin Med
December 2022
Departments of Internal Medicine (Gastroenterology), Tokai University Hachioji Hospital, 1838 Ishikawa-machi, Hachioji, Tokyo 192-0032, Japan.
Article Synopsis
- * She developed symptoms including anal pain, diarrhea, and bloody stools, leading to a colonoscopy that revealed multiple ulcers in the colon.
- * After a suspected diagnosis of lupus enteritis, the patient was treated with endoxan pulse therapy, resulting in rapid symptom improvement and the disappearance of ulcers confirmed by endoscopy.
Clopidogrel IBS Patients Have Higher Incidence of Gastrointestinal Symptoms Influenced by Age and Gender.
Dig Dis Sci
October 2017
Department of Anesthesiology, The Wexner Medical Center, The Ohio State University, 420 West 12th Ave, Room 226, Columbus, OH, 43210, USA.
Background: Clopidogrel is an irreversible antagonist of P2Y receptors (P2YRs) used as an antiplatelet drug to reduce risk of thrombosis. P2YRs are expressed in gastrointestinal (GI) tract where they might regulate GI function.
Aim: To evaluate if blockade of P2YRs by clopidogrel is associated with higher incidence of GI symptoms in patients with irritable bowel syndrome (IBS).
Purpuric herpes zoster in patients in therapy with clopidogrel.
J Clin Virol
August 2015
Department of Pathophysiology and Transplantation, Università degli Studi di Milano, I.R.C.C.S. Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Clopidogrel is an adenosine diphosphate receptor antagonist used for the prevention of vascular events in patients with atherothrombotic diseases manifested by recent myocardial infarction, ischemic stroke or peripheral arterial disease. Diarrhoea, rash and pruritus are rather common side effects of clopidogrel. Other side effects include epistaxis, nausea, abdominal pain, vomiting, gastritis, gastric and duodenal ulcer.
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