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Implementation of the Box-Behnken Design in the Development and Optimization of Methotrexate-Loaded Microsponges for Colon Cancer.
Assay Drug Dev Technol
January 2025
Institute of Pharmaceutical Research, GLA University, Mathura, India.
Diffuse Mesenteric and Bowel Angiodysplasia: A Case Report.
Cureus
December 2024
General Surgery, King Saud Medical City, Riyadh, SAU.
Angiodysplasia is one of the causes of recurrent episodes of lower gastrointestinal (GI) bleeding. Angiodysplasia could be associated with few lesions or multiple diffuse lesions, causing diversity in the clinical presentation of such patients. We report a case of a 19-year-old male presenting with life-threatening gastrointestinal bleeding due to diffuse angiodysplasia of the bowel extending from the jejunum to the sigmoid colon and requiring multiple investigations and management.
View Article and Find Full Text PDFCovert Breast Cancer Metastasis to the Gastrointestinal Tract: Is Extra Vigilance Needed?
ACG Case Rep J
January 2025
Department of Gastroenterology, Hepatology, and Nutrition, Cleveland Clinic, Cleveland, OH.
Breast cancer (BC) is a common cancer in females. Spread to the gastrointestinal tract is rare. This is a 61-year-old woman with history of T2N0M0 lobular BC treated 5 years earlier.
View Article and Find Full Text PDFSynthesized colonoscopy dataset from high-fidelity virtual colon with abnormal simulation.
Comput Biol Med
January 2025
State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, 150080, China. Electronic address:
With the advent of the deep learning-based colonoscopy system, the need for a vast amount of high-quality colonoscopy image datasets for training is crucial. However, the generalization ability of deep learning models is challenged by the limited availability of colonoscopy images due to regulatory restrictions and privacy concerns. In this paper, we propose a method for rendering high-fidelity 3D colon models and synthesizing diversified colonoscopy images with abnormalities such as polyps, bleeding, and ulcers, which can be used to train deep learning models.
View Article and Find Full Text PDFDesigning & optimisation of dual Ca and SO ionic cross-linked sericin/pectin microbeads using response surface methodology for colon-specific delivery.
J Biomater Sci Polym Ed
January 2025
School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior, India.
Ulcerative colitis, a chronic inflammatory condition of the colon, requires precise and targeted treatment, and polysaccharides, with their pH responsiveness and biodegradability, offer an innovative approach for colon-specific drug delivery. This study aims to develop a highly precise drug delivery system with enhanced therapeutic and targeting efficiency for ulcerative colitis, focusing on the preparation, optimisation, and evaluation of dual cross-linked mesalamine-loaded sericin-pectin (DSPs) micro-beads. These beads utilise the pH-responsive and microflora biodegradability properties of polysaccharides for targeted colon delivery, employing the Response Surface Methodology.
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