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Epigenetic Modification of Muscarinic Acetylcholine Receptors in Squamous Cell Carcinoma of the Head and Neck.
Anticancer Res
January 2025
Department of Otolaryngology/Head and Neck Surgery, Hamamatsu University School of Medicine, Shizuoka, Japan;
Background/aim: The five members of the mammalian muscarinic acetylcholine receptor family are encoded by the cholinergic receptor, muscarinic, 1-5 (CHRM1-5) genes. CHRM genes are incriminated in formation of various cancer types, but their roles in head and neck squamous cell carcinoma (HNSCC) are improperly understood. Aberrant epigenetic modifications of specific tumor-suppressor genes and oncogenes are known to promote cancer development.
View Article and Find Full Text PDFIdentification and analysis of immune cell-related genes in cutaneous squamous cell carcinoma and drug network prediction.
Arch Dermatol Res
December 2024
Department of Burn and Plastic Surgery, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province, 550002, China.
Cutaneous squamous cell carcinoma (CSCC) is a malignant skin tumor characterized by the abnormal proliferation of keratinocytes. Immune cells have a very important role in the development of CSCC. Hence, it was vital to screen the immune cell-related biomarkers for the treatment of CSCC.
View Article and Find Full Text PDFCD147 mitochondria translocation induced airway remodeling in asthmatic mouse models by regulating M2 macrophage polarization via ANT1-mediated mitophagy.
Am J Physiol Cell Physiol
December 2024
Departement of Respiratory Medicine, Xinhua hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
CD147 has the potential to serve as a specific target with therapeutic characteristics in several respiratory diseases. Studies have demonstrated that CD147 regulates levels of oxidative phosphorylation (OXPHOS) through the process of mitochondrial translocations. However, there is still limited insight in the distinct mechanism of CD147 in asthmatic macrophages.
View Article and Find Full Text PDFThe dynamic characteristics of the shearer cable drag system.
PLoS One
December 2024
School of Mechanical Engineering, Liaoning Technical University, Fuxin, China.
Based on the 5615 working face of Beisu Coal Mine, a virtual prototype of the shearer cable drag system was developed using the MG2×70/325-BWD electric traction shearer as the carrier, in combination with CERO and ADAMS software. The shearer cable was equivalently modeled using the discrete rigid body method to study the dynamic characteristics of the drag system. This research provides a foundation for the design and optimization of both the cable and cable clamps.
View Article and Find Full Text PDFMulti-Trophic Level Responses to Marine Heatwave Disturbances in the California Current Ecosystem.
Ecol Lett
December 2024
Florida State University, Tallahassee, Florida, USA.
Marine heatwaves (MHWs) caused by multiple phenomena with days to months duration are increasingly common disturbances in ocean ecosystems. We investigated the impacts of MHWs on pelagic communities using spatially resolved time-series of multiple trophic levels from the Southern California Current Ecosystem. Indices of phytoplankton biomass mostly declined during MHWs because of reduced nutrient supply (excepting Prochlorococcus) and were generally more sensitive to marine heatwave intensity than duration.
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