We report preliminary results of a three year follow-up of ten children affected with apparently isolated corpus callosum agenesis (prenatal diagnosis). This population was collected from a multicenter prospective study: annual survey included physical examination, developmental outcome and psychometric evaluation. Febril convulsions appeared to be more frequent than in the general population; developmental outcome was normal at the last evaluation. Follow-up has to be performed up to 10 years to determine more accurately prognosis of isolated corpus callosum agenesis.
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Am J Perinatol
January 2025
Department of Pediatrics, Division of Neonatology, Oregon Health & Science University, Portland, United States.
Objective: To determine the prevalence of septo-optic-dysplasia (SOD) in patients with prenatally identified absent cavum septi pellucidi (CSP), agenesis of the corpus callosum (ACC) or dysgenesis of the corpus callosum (DCC).
Study Design: This retrospective chart review investigated neonates prenatally diagnosed with an absent CSP, ACC, or DCC who were admitted to a single quaternary academic medical center in the Pacific Northwest between 2016-2023. This prenatal diagnosis prompted a routine and protocolized postnatal workup for SOD including laboratory evaluation, imaging, and specialty consultation.
Cureus
December 2024
Neurology, Sheikh Shakhbout Medical City (SSMC) and Mayo Clinic, Abu Dhabi, ARE.
The corpus callosum is a large subcortical white matter region in the brain that contains fiber connecting both cerebral hemispheres together; it has a rich blood supply; hence, infarction in this region is rare. There are a few reported cases of corpus callosal infarction, and here we present our patient who had a clinical presentation that was not suggestive of corpus callosal infarction. However, an MRI brain confirmed the location, and the patient was managed following the standard stroke treatment, and vascular risk factors were addressed and managed.
View Article and Find Full Text PDFBehav Res Methods
January 2025
Department of Sport and Health Sciences, University of Potsdam, Potsdam, Germany.
We introduce a sentence corpus with eye-movement data in traditional Chinese (TC), based on the original Beijing Sentence Corpus (BSC) in simplified Chinese (SC). The most noticeable difference between TC and SC character sets is their visual complexity. There are reaction time corpora in isolated TC character/word lexical decision and naming tasks.
View Article and Find Full Text PDFPediatr Neurol
December 2024
Department of Radiology, Infocus Diagnostics, Ahmedabad, Gujarat, India.
Background: Thick fetal corpus callosum (CC) is a rare finding and its significance in isolation is not clear. In this retrospective study, we aim to gain insight into the microarchitecture of CC in a cohort of fetuses with thick and short CC (isolated or associated with mild extra-/intracranial abnormalities) as seen on ultrasound (US), by using prenatal magnetic resonance (MR) diffusion tensor imaging (DTI) with fiber tractography, thereby allowing better characterization for postnatal prognosis.
Methods: Twelve fetuses met the inclusion criteria on US.
Neuroimage Rep
December 2024
Department of Pediatrics, Division of Developmental-Behavioral Pediatrics, Stanford University, Stanford, CA, USA.
Background: Severe neonatal inflammatory conditions in very preterm infants (VPT: <32 weeks gestational age, GA) are linked to adverse neurodevelopmental outcomes. Differences in white matter (WM) microstructure of the corpus callosum (CC) have been observed at age 6 in VPT children with a history of severe neonatal inflammation. The goal of this study was to determine whether these CC differences can be detected at term-equivalent age using diffusion MRI (dMRI), and whether neonatal inflammation is associated with altered WM in additional tracts implicated in the encephalopathy of prematurity.
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