Purpose: To evaluate a ionization chamber on-line portal imaging system in routine clinical radiotherapy of rectum cancers.
Patients And Methods: Megavolt portal images were obtained using a fast electronic megavoltage radiotherapy imaging system in 13 cases of pelvic fields. A total of 208 portal images and 13 simulator films were used to determine the values of set-up deviations in the X-Z-directions of a fixed co-ordinate system, and of the rotation fields (R).
Results: Mean standard deviations of the difference between simulation and treatment images were 3.2 mm and 0.9 mm for X and Z, 3.6 mm for the rotation fault. The standard deviations were, respectively, 7.1 mm, 7.1 mm and 1.5 mm. The cumulative frequency distributions revealed that 80% and 95% of the absolute differences were less than 10 mm and 17.5 mm, respectively.
Conclusion: These results indicate the difficulty of a reproducible daily set-up. A weekly control could be proposed in order to increase the quality of pelvic site treatment. The introduction of masks to improve the set-up is also discussed.
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Clin Trials
December 2024
Medical Research Council Clinical Trials Unit, University College London, London, UK.
Background: There is increasing recognition that the interpretation of active-controlled HIV prevention trials should consider the counterfactual placebo HIV incidence rate, that is, the rate that would have been observed if the trial had included a placebo control arm. The PrEPVacc HIV vaccine and pre-exposure prophylaxis trial (NCT04066881) incorporated a pre-trial registration cohort partly for this purpose. In this article, we describe our attempts to model the counterfactual placebo HIV incidence rate from the registration cohort.
View Article and Find Full Text PDFTunis Med
December 2024
Pneumology Department, Gabès University Hospital, Faculty of Medicine of Sfax, Gabès, Tunisia.
Introduction: Information on the use of tobacco and other illicit substances by young people is an essential element for the implementation of appropriate preventive measures.
Aim: To estimate the prevalence of smoking, alcohol and drug use among high school students in the city of Gabes.
Methods: Cross-sectional survey carried out in 2022 in 5 schools in the city of Gabes, southern Tunisia, by a self-administered questionnaire.
PLoS One
December 2024
Department of Earth and Environmental Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.
Monitoring the seasonal and diurnal variations in headwater stream metabolic regimes can provide critical information for understanding how ecosystems will respond to future environmental changes. In East Fork Creek, a headwater stream in middle Tennessee, week-long field campaigns were set up each month from May 2022 to May 2023 to collect stream metabolism estimators. In a more extensive field campaign from July 2-5 in 2022, diel signals were observed for temperature, pH, turbidity, and concentrations of Ca, Mg, K, Se, Fe, Ba, chloride, nitrate, DIC, DO, DOC, and total algae.
View Article and Find Full Text PDFExtracell Vesicles Circ Nucl Acids
May 2024
REMAR-IGTP Group, Health Science research Institute Germans Trias i Pujol (IGTP), Can Ruti Campus, Badalona 08916, Spain.
Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) have been reported to hold great potential as cell-free therapies due to their low immunogenicity and minimal toxicity. However, the large doses of MSC-EVs that are required for their clinical application highlight the urgency of finding a large-scale system for MSC-EV manufacture. In this study, we aimed to set up a hollow fiber bioreactor system for the continuous homogenous production of functional and high-quality MSC-EVs.
View Article and Find Full Text PDFRev Panam Salud Publica
December 2024
The University of the West Indies at Cave Hill Bridgetown, Saint Michael Barbados The University of the West Indies at Cave Hill, Bridgetown, Saint Michael, Barbados.
Objective: We describe the daily operations of the Cohorts Consortium of Latin America and the Caribbean (CC-LAC), detailing the resources required and offering tips to Caribbean researchers so this guide can be used to start a data pooling project.
Methods: The CC-LAC began by developing a steering committee - that is, a team of regional experts who guided the project's set up and operations. The Consortium invites investigators who agree to share individual-level data about topics of interest to become members and they then have input into the project's goals and operations; they are also invited to coauthor papers.
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