Arrhythmogenic effects of phenothiazines appear to be associated with sudden death, whereas respiratory complications have received little attention. In this report we describe 5 cases with accompanying obstruction of the airways after intramuscular injections of levomepromazine (LPZ), a potent sedative phenothiazine, in combination with intravenous injections of benzodiazepine (BZ) during a 3-month period in a psychiatric intensive care unit. Two out of 5 cases were unpredictable because obstruction of the airways occurred 2 hours or more after the last injection. As compared with patients who received parenteral (intravenous or intramuscular) injections during the same period, the dose of intramuscular LPZ was significantly large in the 5 cases with obstruction of the airways. All 5 of these cases received intramuscular LPZ 0.52 mg/kg or more. In contrast, there was no patient with obstruction of the airways who received only intramuscular LPZ, the combination of LPZ and HDL, or BZ and HDL. The occurrence of obstruction of the airways among patients who received both intramuscular LPZ and intravenous BZ was significantly higher than among patients who received other drug regimes. These preliminary results suggest that the intramuscular use of LPZ with intravenous BZ may be a risk for obstruction of the airways.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1055/s-2007-979313 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Management of Severe Subcutaneous Emphysema With a Subcutaneous Cannula: A Life-Saving Approach.
Cureus
December 2024
Division of Respiratory Medicine, Universiti Malaya Medical Centre, Kuala Lumpur, MYS.
Subcutaneous emphysema is a well-known complication of chest tube insertion that can become life-threatening. Severe cases often progress rapidly, necessitating prompt intervention to prevent complications such as airway obstruction and respiratory failure. We report the case of a 57-year-old man who developed extensive subcutaneous emphysema following chest tube insertion.
View Article and Find Full Text PDFHygrometry behavior during high-flow nasal oxygen therapy and non-invasive mechanical ventilation: A narrative review of bench to clinical studies.
J Intensive Med
October 2024
Intensive Care Unit, Hospital Morales Meseguer, Murcia, Spain.
Recently, there has been growing interest in knowing the best hygrometry level during high-flow nasal oxygen and non-invasive ventilation (NIV) and its potential influence on the outcome. Various studies have shown that breathing cold and dry air results in excessive water loss by nasal mucosa, reduced mucociliary clearance, increased airway resistance, reduced epithelial cell function, increased inflammation, sloughing of tracheal epithelium, and submucosal inflammation. With the Coronavirus Disease 2019 pandemic, using high-flow nasal oxygen with a heated humidifier has become an emerging form of non-invasive support among clinicians.
View Article and Find Full Text PDFTemperature-Controlled Radiofrequency Treatment of the Nasal Valve in Patients With Nasal Obstruction: Long-Term Outcomes.
Otolaryngol Head Neck Surg
January 2025
Madison ENT & Facial Plastic Surgery, New York, New York, USA.
Objective: To evaluate the efficacy, safety, and durability of temperature-controlled radiofrequency (TCRF) treatment of the nasal valve in patients with severe or extreme nasal airway obstruction (NAO).
Study Design: A long-term, prospective, multicenter, single-blind, randomized controlled trial.
Setting: Sixteen otolaryngologic clinics and academic centers.
Polysomnographic endotypes of successful multilevel upper airway surgery for obstructive sleep apnea.
Sleep
January 2025
Department of Otorhinolaryngology Head and Neck Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 600 Yishan Road, Shanghai, China.
Study Objectives: Multilevel upper airway surgery is effective for some patients with obstructive sleep apnea (OSA), but prediction the response to surgery remains a challenge. The underlying endotypes of OSA include upper airway collapsibility, muscle compensation, loop gain, and the arousal threshold. This study aimed to explore the effect of surgery on polysomnography (PSG)-derived OSA endotypes and establish a surgical response prediction model.
View Article and Find Full Text PDFAssessment of the correlation between the volume of tongue, oral cavity, tongue/oral cavity volume ratio and the upper airway in unilateral cleft subjects: A CBCT study.
Oral Radiol
January 2025
Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Objectives: The current study was conducted to assess the volume of the tongue, oral cavity, and tongue/oral cavity and their correlation with the volume of the upper airway in cleft subjects compared with the control group.
Methods: The study population included 60 CBCT images from dental school. The sample comprised 30 unilateral cleft patients and 30 sex and age-matched healthy subjects.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!