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Similar Publications
Long-term utilization and benefit of luspatercept in transfusion-dependent, erythropoiesis-stimulating agent-refractory or -intolerant patients with lower-risk myelodysplastic syndromes with ring sideroblasts.
Leukemia
November 2023
Service d'Hématologie Séniors, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris and Université Paris 7, Paris, France.
A longitudinal analysis of paroxysmal nocturnal haemoglobinuria-type cells in patients with bone marrow failure: Results of a prospective multi-centre study in Japan.
Br J Haematol
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Department of Hematology, Faculty of Medicine, Institute of Medical Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.
Article Synopsis
- A nationwide study involving 2402 patients investigated the prevalence of glycosylphosphatidylinositol-anchored protein-deficient (GPI[-]) cells, specifically PNH-type cells, in individuals with acquired aplastic anaemia (AA) and myelodysplastic syndrome (MDS) using high-sensitivity flow cytometry.
- PNH-type cells were found in 52.6% of AA patients and 13.7% of MDS patients, while none were present in patients with refractory anaemia having ringed sideroblasts or excess blasts.
- The study concluded that PNH-type granulocyte levels can change over time in patients with AA and highlighted that having ≥1% PNH-type granul
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