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A rare case of paradoxical embolization due to an acquired extracardiac right-to-left shunt during covid-19 infection: Every street leads to heart.
J Cardiol Cases
October 2024
Pediatric Cardiology Unit, University of Campania "Luigi Vanvitelli", AORN "Ospedali dei Colli", Monaldi Hospital, Naples, Italy.
Unlabelled: Right-to-left shunt may be a cause of paradoxical embolization (and cryptogenic cerebral ischemic events). Patent foramen ovale and pulmonary arterio-venous malformations are the most common cause of paradoxical embolization; however, some rare cardiovascular lesions may cause a right-to-left shunt with consequent paradoxical embolization. We describe a case of a young child with superior sinus venosus atrial septal defect who underwent surgical closure and developed a cryptogenic cerebral ischemic attack due to a rare cause of paradoxical embolization, during a long-term follow-up.
View Article and Find Full Text PDFTrim the sail: A rare cause of newborn hypoxia.
Ann Pediatr Cardiol
December 2024
Department of Pediatrics, Division of Neonatology, University of Illinois College of Medicine - Peoria, Peoria, IL, USA.
The right venous valve is critical to the proper development of the fetal heart. As the right venous valve degenerates later in fetal development, residual structures can remain, such as the terminal crest, Eustachian valve, Thebesian valve, and a prominent Chiari network, with a sail-like appearance resembling a spinnaker. While these structures are often incidentally found on adult echocardiograms, we present a case of a term neonate with hypoxia secondary to a persistent right valve of the sinus venosus.
View Article and Find Full Text PDFDevelopment of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human.
J Transl Med
January 2025
Department of Anatomy & Embryology, Leiden University Medical Center, P.O. Box 9600, Postal Zone: S-1-P, 2300 RC, Leiden, The Netherlands.
Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking.
View Article and Find Full Text PDFMolecular insights into developmental toxicity induced by PCB77 exposure on zebrafish via integrating transcriptomics with adverse outcome pathway.
Sci Total Environ
January 2025
Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China; CAS Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address:
Polychlorinated biphenyls (PCBs), a typical type of persistent organic pollutants (POPs), were previously widely employed as insulating and heat exchange fluids in transformers and capacitors. Despite knowledge of its adverse effects, the precise mechanism underlying PCB77 toxicity remains enigmatic. In this study, we utilized zebrafish as a model organism to explore the toxic effects of various concentrations of PCB77 (10, 200, and 1000 μg/L) and its molecular toxicity mechanisms.
View Article and Find Full Text PDFTeratogenicity, cardiac toxicity, neurotoxicity and genotoxicity in zebrafish embryo-larvae exposed to 4-bromodiphenyl ether.
Toxicol Res (Camb)
January 2025
Department of Zoology, Guru Nanak Dev University, Amritsar 143005, India.
Polybrominated diphenyl ethers (PBDEs) have been classified as a new class of persistent organic pollutants by the United Nations Environment Programs in 2009. In environment, PBDEs can undergo the degradation process to form less brominated diphenyl ethers. In the present study, the 96 h LC value for 4-bromodiphenyl ether (BDE-3) was found to be 3.
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