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Clinical significance and pro-oncogenic function of DBF4 in clear cell renal cell carcinoma.
BMC Urol
January 2025
Institute of Clinical Medicine, The Second affiliated Hospital of Hainan Medical University, 368th Yehai Avenue, Haikou, Hainan, 570311, China.
Background: Clear cell renal cell carcinoma (ccRCC) is the most common malignant urological tumor, and regrettably, and is insensitive to chemotherapy and radiotherapy, resulting in poor patient outcomes. DBF4 plays a critical role in DNA replication and participates in various biological functions, making it an attractive target for cancer treatment. However, its significance in ccRCC has not yet been explored.
View Article and Find Full Text PDFDevelopment of B7-H3 targeted CAR-T cells for renal cell carcinoma therapy: in vitro and in vivo efficacy.
Clin Transl Oncol
November 2024
Institute of Clinical Medicine, the Second Affiliated Hospital of Hainan Medical University, 368 Yehai Avenue, Haikou, 570311, Hainan, China.
Article Synopsis
- * Researchers confirmed high B7-H3 expression in RCC using various methods, developed a B7-H3-specific CAR-T cell, and proved their effectiveness in lab experiments and mouse models, highlighting increased cytotoxic activity and tumor growth inhibition.
- * The findings suggest that B7-H3 CAR-T cells could be a viable immunotherapy option for treating RCC, showing promise in targeting and destroying cancer cells.
Determination of Aloin A, Aloin B, and Aloe-Emodin in Raw Materials and Finished Products Using HPLC Multi-Laboratory Validation Study, AOAC 2016.09, Final Action Status.
J AOAC Int
September 2024
Herbalife Nutrition, 990 West 190th Street, Torrance, CA, 90502.
Article Synopsis
- A multi-laboratory validation study was conducted to assess the AOAC OMA 2016.09 method, involving eight labs worldwide that tested six different raw materials and formulated products, all meeting acceptance criteria.
- The study focused on evaluating specificity, precision, linearity/range, system suitability, limit of detection (LOD), and limit of quantitation (LOQ), as accuracy and ruggedness had already been validated previously.
- Results indicated no major interferences in chromatograms for aloin A, aloin B, and aloe-emodin, with high precision (≤ 0.05 ppm differences) and strong linearity (R ≥ 0.999 across standards), confirming the method's reliability.
Position: A study protocol for the prevention of fall injuries in french special forces selection courses using a body-centered intervention.
PLoS One
November 2023
French Armed Forces Biomedical Research Institute, Unit of Neurophysiology of Stress, Brétigny-sur-Orge France.
Introduction: The Military Physical and Sports Training program was developed by the French Army in order to train, optimize, and maintain individual readiness. Although the health benefits of sport practice do not need to be demonstrated, such activities can cause acute musculoskeletal injuries that need to be addressed. The prevalence of lower limb injury is rather high in the French military population and, in particular, ranges from 15 to 45% during Special Forces selection courses.
View Article and Find Full Text PDFApplication of a modified tetra-primer ARMS-PCR assay for rapid Panax species identity authentication in ginseng products.
Sci Rep
September 2023
Corporate Center of Excellence Quality Laboratory, Herbalife International of America, Inc., 950 W 190th Street, Torrance, CA, 90502, USA.
Article Synopsis
- Panax ginseng products often get mixed with other species, making it important to have a reliable method to confirm their authenticity.
- This study developed a tetra-primer ARMS-PCR assay that accurately identifies P. ginseng and detects potential adulteration at different processing stages.
- The modified assay proved effective in distinguishing P. ginseng from similar species while enhancing sensitivity and specificity, providing a valuable tool for quality control in ginseng products.
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