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Redefining Ketamine Pharmacology for Antidepressant Action: Synergistic NMDA and Opioid Receptor Interactions?
Am J Psychiatry
January 2025
Biobehavioral Imaging and Molecular Neuropsychopharmacology Section, NIDA, Baltimore (Levinstein, Budinich, Michaelides); Department of Pathology and Experimental Therapeutics, Institute of Neurosciences, University of Barcelona, L'Hospitalet de Llobregat, Barcelona (Bonaventura); Neuropharmacology and Pain Group, Neuroscience Program, IDIBELL-Bellvitge Biomedical Research Institute, L'Hospitalet de Llobregat, Barcelona (Bonaventura); Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford (Schatzberg); Experimental Therapeutics and Pathophysiology Branch, NIMH, Bethesda (Zarate); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore (Michaelides).
Ketamine is a racemic compound and medication comprised of ()-ketamine and ()-ketamine enantiomers and its metabolites. It has been used for decades as a dissociative anesthetic, analgesic, and recreational drug. More recently, ketamine, its enantiomers, and its metabolites have been used or are being investigated for the treatment of refractory depression, as well as for comorbid disorders such as anxiety, obsessive-compulsive, and opioid use disorders.
View Article and Find Full Text PDFTraining Community Clinicians in Implementing CBT-ERP for Youth with OCD: A Pilot Study in Australian Community Mental Health Services.
Child Psychiatry Hum Dev
January 2025
School of Applied Psychology, Griffith University, Gold Coast, QLD, Australia.
This pilot study evaluated the outcomes associated with a training workshop in cognitive-behavioural therapy with exposure and response prevention (ERP) for youth with obsessive-compulsive disorder (OCD) aimed at improving clinicians' capabilities and motivations. Questionnaires and role-plays were completed by 17 Australian clinicians working across community youth (i.e.
View Article and Find Full Text PDFCurrent Advances in Behavioral Addictions: From Fundamental Research to Clinical Practice.
Am J Psychiatry
December 2024
General Psychology-Cognition, Faculty of Computer Science, University of Duisburg-Essen, Germany (Brand, Antons, Wegmann); Center for Behavioral Addiction Research, Center for Translational Neuro- and Behavioral Sciences, University Hospital Essen, University of Duisburg-Essen, Germany (Brand, Antons, Wegmann); Erwin L. Hahn Institute for Magnetic Resonance Imaging, Essen, Germany (Brand, Antons); Department of Psychology, University of Montreal, Montreal (Bőthe); Interdisciplinary Research Center on Intimate Relationship Problems and Sexual Abuse (CRIPCAS), Montreal (Bőthe); College of Education, Psychology, and Social Work, Flinders University, Adelaide, Australia (Demetrovics, King); Institute of Psychology, ELTE Eötvös Loránd University, Budapest (Demetrovics); Center of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar (Demetrovics); School of Life and Medical Sciences, University of Hertfordshire, Hatfield, UK (Fineberg); Hertfordshire Partnership University NHS Foundation Trust, Welwyn Garden City, UK (Fineberg); University of Cambridge School of Clinical Medicine, Cambridge, UK (Fineberg); Department of Clinical Psychology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona (Jimenez-Murcia); Ciber Physiopathology of Obesity and Nutrition, Instituto de Salud Carlos III, Barcelona (Jimenez-Murcia); Psychoneurobiology of Eating and Addictive Behaviors Group, Neurosciences Program, IDIBELL, Barcelona (Jimenez-Murcia); Department of Clinical Sciences, School of Medicine and Health Sciences, University of Barcelona, Barcelona (Jimenez-Murcia); Psychology Services of the University of Barcelona, Barcelona (Jimenez-Murcia); Instituto de Investigación, Transferencia e Innovación, Universidad Internacional de La Rioja, La Rioja, Spain (Mestre-Bach); Department of General Psychology, University of Padova, Padua, Italy (Moretta); Department of Psychosomatic Medicine and Psychotherapy, Hannover Medical School, Hanover, Germany (Müller); Departments of Psychiatry, Neuroscience, and Child Study and Wu Tsai Institute, Yale University School of Medicine, New Haven, CT (Potenza); Connecticut Council on Problem Gambling, Wethersfield, CT (Potenza); Connecticut Mental Health Center, New Haven, CT (Potenza).
Article Synopsis
- Gambling disorder is the only recognized behavioral addiction in DSM-5, while Internet gaming disorder is noted for further research; other potential disorders include compulsive sexual behavior, compulsive shopping, and social media issues.
- These disorders are clinically relevant and often coexist with conditions like depression and anxiety, with validated diagnostic tools available but no approved medications for treatment.
- Cognitive-behavioral therapy shows the most promise, highlighting the need for active screening and public health efforts, along with further research into treatment methods that combine various therapeutic approaches.
Mindfulness as a Way of Reducing Automatic Constraints on Thought.
Biol Psychiatry Cogn Neurosci Neuroimaging
November 2024
Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address:
The number of mindfulness-based wellness promotion programs offered by institutions, by governments, and through mobile apps has grown exponentially in the last decade. However, the scientific understanding of what mindfulness is and how it works is still evolving. Here, I focus on 2 common mindfulness practices: focused attention (FA) and open monitoring (OM).
View Article and Find Full Text PDFAtlas of Gray Matter Volume Differences Across Psychiatric Conditions: A Systematic Review With a Novel Meta-Analysis That Considers Co-Occurring Disorders.
Biol Psychiatry
November 2024
Institut d'Investigacions Biomèdiques August Pi I Sunyer, Barcelona, Spain; Department of Medicine, University of Barcelona, Institute of Neuroscience, Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental, Instituto de Salud Carlos III, Madrid, Spain. Electronic address:
Background: Regional gray matter volume (GMV) differences between individuals with mental disorders and comparison participants may be confounded by co-occurring disorders. To disentangle disorder-specific GMV correlates, we conducted a large-scale multidisorder meta-analysis using a novel approach that explicitly models co-occurring disorders.
Methods: We systematically reviewed voxel-based morphometry studies indexed in PubMed and Scopus up to January 2023 that compared adults with major mental disorders (anorexia nervosa, schizophrenia spectrum, anxiety, bipolar, major depressive, obsessive-compulsive, and posttraumatic stress disorders plus attention-deficit/hyperactivity, autism spectrum, and borderline personality disorders) with comparison participants.
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