AI Article Synopsis

Article Abstract

Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine splenic axons in vitro and compared with terminals in the vas deferens. In the synaptic differentiations taking place proximally synapsin could only be detected on the accumulating elements of the axonal reticulum. Large dense granules and clusters of small synaptic vesicles were negative. Synaptophysin was restricted to these clusters. In the vas deferens, co-localization of synapsin and synaptophysin could be seen on small vesicles. From their formation small synaptic vesicles carry synaptophysin. Synapsin may be involved in the dynamic membrane changes taking place at the ligation. At a functional terminal, synapsin shifts to small synaptic vesicles.

Download full-text PDF

Source
http://dx.doi.org/10.1016/s0006-8993(98)00617-9DOI Listing

Publication Analysis

Top Keywords

synaptic vesicles
16
synapsin synaptophysin
12
small synaptic
12
bovine splenic
8
synaptophysin synapsin
8
vas deferens
8
synapsin
7
synaptophysin
6
synaptic
5
vesicles
5

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!