A retrospective study was undertaken to evaluate the long-term results of reduction mammaplasties. Of special interest was the extent to which the amount of breast tissue removed correlated with pain relief after reduction mammaplasty. One hundred fourteen patients underwent an average reduction of 1,266 g. The follow-up time was 7.7 years. Ninety-one percent of the patients noticed a decrease in shoulder, neck, and back pain, and lessening of brassiere shoulder grooves. Nine percent noticed no change at all, and only 1 patient complained of increased breast pain after the operation. In 11% of the patients, pain was not an indicator for the operation. We could find a significant correlation (r = 0.36, p = 0.001) between the amount of tissue resected and pain relief after surgery. The follow-up time did not correlate with a regaining of the physical complaints (r = 0.15, p = 0.2). Patients gained an average of 1.2 kg and had an average preoperative overweight of 118%. From the results of our study we were able to conclude that an average reduction of 500 to 600 g of breast tissue on both sides has a long-lasting effect in reducing shoulder and back pain.
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http://dx.doi.org/10.1097/00000637-199809000-00003 | DOI Listing |
Ann Surg Oncol
January 2025
Department of Surgery, Duke University Medical Center, Durham, NC, USA.
Hernia
January 2025
Department of General Surgery, Horsens Regional Hospital, Horsens, Denmark.
Purpose: Parastomal hernia is a frequent complication after stoma construction, with increasing incidence over time. Surgical repair is reported with a high recurrence rate and the evidence on the topic is limited. We conducted a retrospective study to evaluate the incidence of recurrence after parastomal hernia repair and assessed the risk factors and predictors for recurrence at the Regional Hernia Center at Horsens Regional Hospital, Denmark.
View Article and Find Full Text PDFJ Xenobiot
December 2024
Amity Institute of Biotechnology, Amity University Rajasthan, Jaipur 303002, India.
Addressing the consequences of exposure to endocrine-disrupting chemicals (EDCs) demands thorough research and elucidation of the mechanism by which EDCs negatively impact women and lead to breast cancer (BC). Endocrine disruptors can affect major pathways through various means, including histone modifications, the erroneous expression of microRNA (miRNA), DNA methylation, and epigenetic modifications. However, it is still uncertain if the epigenetic modifications triggered by EDCs can help predict negative outcomes.
View Article and Find Full Text PDFIET Syst Biol
January 2025
School of Computer, University of South China, Hengyang, Hunan, China.
Spatially resolved transcriptomics technologies potentially provide the extra spatial position information and tissue image to better infer spatial cell-cell interactions (CCIs) in processes such as tissue homeostasis, development, and disease progression. However, methods for effectively integrating spatial multimodal data to infer CCIs are still lacking. Here, the authors propose a deep learning method for integrating features through co-convolution, called SpaGraphCCI, to effectively integrate data from different modalities of SRT by projecting gene expression and image feature into a low-dimensional space.
View Article and Find Full Text PDFFront Pharmacol
January 2025
Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Introduction: Triple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer to treat. While previous studies have demonstrated that ginsenoside Rh2 induces apoptosis in TNBC cells, the specific molecular targets and underlying mechanisms remain poorly understood. This study aims to uncover the molecular mechanisms through which ginsenoside Rh2 regulates apoptosis and proliferation in TNBC, offering new insights into its therapeutic potential.
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