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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Plaques are a hallmark feature of Alzheimer's disease (AD). We found the loss of mucosal-associated invariant T (MAIT) cells and its antigen-presenting molecule MR1 caused a delay in plaque pathology development in AD mouse models. However, it remains unknown how this axis is impacting microglial response and dystrophic neurites.
View Article and Find Full Text PDFABCA1 promote tumor environment heterogeneity via epithelial mesenchymal transition in Huh7 and HepG2 liver cancer cell.
Front Pharmacol
December 2024
Department of Hepatobiliary Pancreatic Surgery, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
In this study, we delve into the intrinsic mechanisms of cell communication in hepatocellular carcinoma (HCC). Initially, employing single-cell sequencing, we analyze multiple malignant cell subpopulations and cancer-associated fibroblast (CAF) subpopulations, revealing their interplay through receptor-ligand interactions, with a particular focus on SPP1. Subsequently, employing unsupervised clustering analysis, we delineate two clusters, C1 and C2, and compare their infiltration characteristics using various tools and metrics, uncovering heightened cytotoxicity and overall invasion abundance in C1.
View Article and Find Full Text PDFRespiratory processes of early-evolved hyperthermophiles in sulfidic and low-oxygen geothermal microbial communities.
Nat Commun
January 2025
Department of Microbiology and Cell Biology, Montana State University, Bozeman, MT, USA.
Thermophilic microbial communities growing in low-oxygen environments often contain early-evolved archaea and bacteria, which hold clues regarding mechanisms of cellular respiration relevant to early life. Here, we conducted replicate metagenomic, metatranscriptomic, microscopic, and geochemical analyses on two hyperthermophilic (82-84 °C) filamentous microbial communities (Conch and Octopus Springs, Yellowstone National Park, WY) to understand the role of oxygen, sulfur, and arsenic in energy conservation and community composition. We report that hyperthermophiles within the Aquificota (Thermocrinis), Pyropristinus (Caldipriscus), and Thermoproteota (Pyrobaculum) are abundant in both communities; however, higher oxygen results in a greater diversity of aerobic heterotrophs.
View Article and Find Full Text PDFSegmental vitiligo: autoimmune pathogenesis, neuronal mechanisms, and somatic mosaicism.
Int J Dermatol
December 2024
Department of Dermatology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
Vitiligo is a common depigmentation disorder classified into nonsegmental vitiligo (NSV) and segmental vitiligo (SV). SV accounts for 5-27.9% of patients with vitiligo.
View Article and Find Full Text PDFExploring the relationships between complex post-traumatic stress disorder and depression symptoms in the context of childhood maltreatment through network analysis.
Child Abuse Negl
December 2024
Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, Beijing 100875, China.
Background: Individuals with a history of childhood maltreatment commonly experience the co-occurrence of complex post-traumatic stress disorder (CPTSD) and depression, but the underlying mechanisms of their comorbidities remain unclear.
Methods: We recruited 2740 college students, including 1366 who experienced childhood maltreatment to assess the co-occurrence network of CPTSD and depression symptoms. We constructed a Gaussian graphical model to visualize the associations between symptoms and a directed acyclic graph to explore inferred relationships among symptoms.
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