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Central and nephrogenic diabetes insipidus: updates on diagnosis and management.
Front Endocrinol (Lausanne)
January 2025
Department of Endocrinology, Walter Reed National Military Medical Center, Bethesda, MD, United States.
Diabetes insipidus (DI) is a rare endocrine disease involving antidiuretic hormone (ADH), encompassing both central and nephrogenic causes. Inability to respond to or produce ADH leads to inability of the kidneys to reabsorb water, resulting in hypotonic polyuria and, if lack of hydration, hypernatremia. DI cannot be cured and is an unfamiliar disease process to many clinicians.
View Article and Find Full Text PDF[Correction of the effect of vitamin K antagonists and antiplatelet agents in hemorrhagic stroke].
Zh Vopr Neirokhir Im N N Burdenko
December 2024
Burdenko Neurosurgical Center, Moscow, Russia.
Background: Hemorrhagic stroke (HS) is associated with high risk of mortality or disability. To date, up to 25% of HSs are associated with anticoagulants and antiplatelet agents. Early hemostatic therapy and correction of effect of antithrombotic drugs in patients with HS significantly reduce the risk of adverse outcomes.
View Article and Find Full Text PDFDoes Desmopressin Reduce Intraoperative Bleeding in Patients Who Undergo Nasal Surgery? A Systematic Review and Meta-Analysis.
J Rhinol
March 2024
Department of Otolaryngology-Head and Neck Surgery, Bucheon Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Background And Objectives: This study aimed to determine the efficacy of prophylactic desmopressin administered via the intranasal or intravenous route in reducing intraoperative bleeding during nasal surgery. We conducted a meta-analysis of the relevant literature to investigate the role of preoperative desmopressin in minimizing bleeding complications associated with nasal surgery.
Methods: We screened the relevant literature published before February 2023.
Stability of Diluted Desmopressin Acetate Intranasal Solution at 0.01 mg/mL.
Int J Pharm Compd
December 2024
Université de Montréal, Montreal, Quebec, Canada.
Objective: In pediatrics, weight-based doses can be very small, leading to measuring tiny volumes of the commercial desmopressin nasal solution at 0.1mg/mL, which reduces precision and increases the risk of error. Since stability of the desmopressin acetate solution diluted at 0.
View Article and Find Full Text PDFAdipsic arginine vasopressin deficiency: challenges in managing the intricate interplay of adipsia with polyuria.
BMJ Case Rep
October 2024
Endocrinology and Metabolism, All India Institute of Medical Science, Bhopal, Madhya Pradesh, India
Article Synopsis
- Adipsic arginine vasopressin deficiency (AAVP-D) occurs due to hypothalamic dysfunction, often linked to conditions like craniopharyngiomas, which makes management difficult since key mechanisms for regulating plasma osmolality are impaired.
- Patients with AAVP-D can suffer from severe dehydration and elevated sodium levels (hypernatraemia), leading to frequent emergency visits despite treatment with desmopressin, an arginine vasopressin analogue.
- A case study highlights the successful management of AAVP-D through careful water intake regulation and desmopressin administration, resulting in stable serum sodium levels (140-150 mmol/L) and no emergency visits over a three-month period.
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