By using single-spore culture method in three points standard system, additional colonies and sectors (areas) are formed due to the dislocation of growing colonies and dissemination of conidia, respectively. Droplets (resulting from condensation of the exudate on Petri dish lids) falling on or touching the conidial masses are responsible for sectors (areas) and additional colonies formation.
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Front Pharmacol
January 2025
Graduate School, Hunan University of Chinese Medicine, Changsha, Hunan, China.
Background: TRIB3 has been reported to mediate breast cancer (BC) proliferation and metastasis by interacting with AKT1, and blocking the interaction between TRIB3 and AKT1 can inhibit the progression of BC. Besides, inhibiting TRIB3 to turn "cold tumor" hot has also been proved to be an effective therapeutic strategy for BC. Thus, this study aim to find drugs that can bind to TRIB3 to inhibit BC progression, and further elucidate its mechanism.
View Article and Find Full Text PDFMol Med
January 2025
Department of Urology, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou, 510920, Guangdong, People's Republic of China.
Prostate cancer (PCa) is a highly common type of malignancy and affects millions of men in the world since it is easy to recur or emerge therapy resistance. Therefore, it is urgent to find novel treatments for PCa patients. In the current study, we found that tegaserod maleate (TM), an FDA-approved agent, inhibited proliferation, colony formation, migration as well as invasion, caused the arrest of the cell cycle, and promoted apoptosis of PCa cells in vitro.
View Article and Find Full Text PDFNonsense-mediated decay (NMD) is a eukaryotic surveillance pathway that controls degradation of cytoplasmic transcripts with aberrant features. NMD-controlled RNA degradation acts to regulate a large fraction of the mRNA population. It has been implicated in cellular responses to infections and environmental stress, as well as in deregulation of tumor-promoting genes.
View Article and Find Full Text PDFFish Shellfish Immunol
January 2025
Laboratory of Pathology and Immunology of Aquatic Animals, KLMME, Ocean University of China, 5 Yushan Road, Qingdao, 266003, PR China; Laboratory for Marine Fisheries Science and Food Production Processes, Qingdao Marine Science and Technology Center, Qingdao, Shandong 266237, PR China. Electronic address:
Granulocyte colony stimulating factor (G-CSF) has been shown in mammalia to activate a series of signal transduction systems and exert various biological effects, such as controlling the differentiation, proliferation, and survival of granulocytes, promoting the movement of hematopoietic stem cells from the bone marrow to the bloodstream, and triggering the development of T cells, dendritic cells, and immune tolerance in transplants. In this study, the mRNA of flounder G-CSF (PoG-CSF) and its receptor (PoGCSFR) were detected and widely expressed in all examined tissues with the highest expression in peritoneal cells. G-CSF and GCSFR cells were observed to be abundantly distributed in the leukocytes from the peritoneal cavity, followed by head kidney.
View Article and Find Full Text PDFHeliyon
January 2025
Food Science Department, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt.
The antioxidant extracts considered a very important food additive which promoting the protection of lipid and prolong the shelf life of food products. The aim of this investigation was decrease the time of extraction of hibiscus leaves extract (HLE) and olive leaves extract (OLE) from 48 h to only 6 h without reducing efficiency of these extracts. HPLC assay, scavenging radical activity by DPPH˙ (IC), inhibition lipid peroxidation by both β-Carotene/Linoleic Acid Bleaching (βCB) and Thiobarbituric Acid Reactive Substances (TBARs) assays, antibacterial and antifungal activities measured for different concentrations of ethanolic extracts by conventional extraction (CE) and difference in pressure extraction (DPE) methods, and the results shown a considerable in mean difference ( < 0.
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