The evaluation of the antidiphtheria and antitetanus immunity level is still a topical question. The paper approaches the study of antidiphtheria and antitetanus immunity on age groups in 3,768 and, respectively, 4,001 subjects. In the studied population, the results of estimating immunity revealed an antidiphtheria percentage of 87.16% and a protection level against tetanus of 94.47%. The immunity level against both diphtheria and tetanus varied depending upon the studied age. The highest susceptibility values against diphtheria (29.42%) were recorded in the 6th decade and against tetanus (18.89-28.27%) in the 6th and, respectively, 7th decade. A high antidiphtheria and antitetanus immunity level (over 90%) was reported in children and young people after the IIIrd and IVth boosters).
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Heliyon
November 2024
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Background: Limited data exists regarding population immunity against diphtheria, tetanus, and pertussis in Thailand during the post-COVID-19 pandemic period. This study aimed to evaluate the age-specific seroprevalence of anti-diphtheria toxoid (anti-DT) IgG, anti-tetanus toxoid (anti-TT) IgG, and anti-pertussis toxin (anti-PT) IgG in individuals across diverse age groups in Chonburi province, Thailand following the COVID-19 pandemic.
Methods: Between October 2022 and January 2023, a total of 657 participants from Chonburi Province, Thailand, were included in this study.
EClinicalMedicine
May 2024
Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Background: While maternal pertussis vaccination is a strategy to reduce infant morbidity, safety and immunogenicity data are limited in sub-Saharan Africa. We aimed to evaluate the safety of a single dose of tetanus, diphtheria and acellular pertussis vaccine (Tdap) vaccine compared to tetanus and diphtheria vaccine (Td) vaccine in pregnant women in Bamako, Mali and to assess the pertussis toxin (PT) antibody response at birth.
Methods: In this phase 2, single-centre, randomised, double-blind, active-controlled study, from 23 January 2019 to 10 July 2019, healthy 18-39 year old women in the second trimester of a singleton pregnancy were randomised 2:1 to receive Tdap or Td.
Pathog Immun
February 2024
Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland.
Background: Lymphopenia is common in COVID-19. This has raised concerns that COVID-19 could affect the immune system akin to measles infection, which causes immune amnesia and a reduction in protective antibodies.
Methods: We recruited COVID-19 patients (n = 59) in Helsinki, Finland, and collected plasma samples on 2 to 3 occasions during and after infection.
Vaccine
June 2023
The Academy of Science, The Royal Society of Thailand, Dusit, Bangkok 10300, Thailand. Electronic address:
Background: The pentavalent DTwP-HB-Hib (Shan-5) vaccine was first introduced into the Thailand Expanded Program on Immunization (EPI) in 2019. The Shan-5 vaccine is administered to infants at 2, 4, and 6 months of age, after initial vaccination with monovalent hepatitis B (HepB) and Bacillus Calmette-Guérin (BCG) vaccines at birth. This study compared the immunogenicity of the HepB, diphtheria, tetanus, and Bordetella pertussis antigens incorporated in the EPI Shan-5 vaccine versus the optional pentavalent (DTwP-HB-Hib) Quinvaxem and hexavalent (DTaP-HB-Hib-IPV) Infanrix-hexa vaccine.
View Article and Find Full Text PDFTrop Med Int Health
June 2023
Lao-Lux Laboratory, Institut Pasteur du Laos, Vientiane, Lao People's Democratic Republic.
Objectives: There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents.
Methods: Seven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies.
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