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Network pharmacology and multi-omics validation of the Jianpi-Yishen formula in the treatment of chronic kidney disease.
Front Immunol
January 2025
Department of Geriatrics, Shenzhen Traditional Chinese Medicine Hospital, The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine, Shenzhen, China.
Objective: Chronic kidney disease (CKD) is a major global health problem. In clinical practice, the Chinese patent herbal medicine Jianpi-Yishen (JPYS) formula is commonly used to treat CKD. However, the molecular mechanisms by which JPYS targets and modulates the host immune response remain unclear.
View Article and Find Full Text PDFExploration of the mechanism of tetramethoxyflavone in treating osteoarthritis based on network pharmacology and molecular docking.
Tzu Chi Med J
July 2024
Pharmacy College, Gannan Medical University, Ganzhou, Jiangxi, China.
Objectives: This study aimed to explore the potential mechanisms of TMF (5,7,3',4'-tetramethoxyflavone) in treating osteoarthritis (OA) using network pharmacology and molecular docking.
Materials And Methods: Databases including SwissTargetPrediction, BATMAN-TCM, PharmMapper, TargetNet, SuperPred, and SEA were utilized to screen the targets of TMF. "OA" was used as the disease keyword to predict OA-related genes through GeneCards, Therapeutic Target Database, PharmGKB, Online Mendelian Inheritance in Man, and Comparative Toxicogenomics Database.
Alcohol consumption and allergic diseases: Mendelian randomization evidence from China.
Glob Health Action
December 2024
College of Economics and Management, China Agricultural University, Beijing, China.
Background: The prevalence of allergic diseases in China has risen significantly over the past decades, affecting the quality of life for approximately 40% of the population.
Objectives: This study aimed to integrate survey and genomic data to explore the potential causal relationship between alcohol consumption and allergic diseases.
Method: In collaboration with a leading genetic testing company in China, we collected data on 3,041 participants via an online survey between December 2018 and October 2019.
Fertility problems in men carrying chromosome 7 inversion: A retrospective, observational study.
Medicine (Baltimore)
January 2025
Department of Urology, The First Hospital of Tsinghua University, Beijing, China.
Infertility is a worldwide public health issue. Fifty percent of infertile couples are male-only. A number of male infertility etiologies are significantly influenced by chromosomal abnormalities.
View Article and Find Full Text PDFSerum metabolites and risk of aortic dissection: a two-sample Mendelian randomization study.
Indian J Thorac Cardiovasc Surg
February 2025
Department of Cardiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001 Anhui China.
Purpose: Acute aortic dissection is a serious cardiovascular emergency with a high mortality rate. Its pathogenesis is complex and remains unclear. This study aimed to assess the connection between the levels of genetically predicted circulating metabolites and the risk of aortic dissection.
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