This is a report on 113 patients with chest injuries subjected to treatment over the period 1991 through 1993. Of them 72.5 per cent are with ages ranging from 11 to 30 years, and 94.7 per cent are men. The series includes cases presenting incised penetrating wounds (49.6 per cent), involvement in motor-vehicle road accidents (26.5 per cent) and gunshot wounds (15.9 per cent). Of the total number 23 per cent are polytraumatized. Most of the patients (56.7 per cent) have hemopneumothorax with pleural drainage being the only treatment applied. In 15.9 per cent thoracotomy, laparotomy or thoracotomy plus laparotomy are used. Complications are recorded in 7.1 per cent, with deaths amounting to 2.7 per cent.
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Lakartidningen
January 2025
docent, verksamhetschef, Karolinska centrum för cellterapi (KCC), Karolinska universitetssjukhuset, Stockholm; Karolins-ka ATMP-centrum; institutionen för laboratorie-medicin, Karolinska institutet.
Gene editing is a novel technology within gene therapy, which changes sequences in chromosomal DNA with precision. Even if there are alternative strategies, the Nobel Prize-winning CRISPR/Cas technology has become the dominating principle. During recent years base editing and prime editing, permitting editing without DNA double-strand breaks, have been developed.
View Article and Find Full Text PDFObjective: Transrectal (TR) prostate biopsy is being increasingly abandoned in favour of a transperineal (TP) approach as well as a targeted biopsy only of the index lesion(s). It remains underreported how these changes could impact concordance at final pathology. We aimed to evaluate the impact of transitioning from standard transrectal (sTR) to cognitive targeted transperineal (cog-tTP) biopsy on final pathology including concordance and upgrading.
View Article and Find Full Text PDFChron Respir Dis
January 2025
West Midlands Adult Cystic Fibrosis Centre, Birmingham Heartlands Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
The use of non-invasive ventilation (NIV) in patients with advanced cystic fibrosis (CF) has increased in recent years. Research evidence supports its clinical benefits, but less is known about the patients' experience of its long-term use in a domiciliary setting. To investigate patients' lived experience of using long-term domiciliary NIV.
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