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Bladder sparing management for muscle-invasive bladder cancer after a complete clinical response: ready for prime time?-a narrative review.
Transl Cancer Res
November 2024
Section of Urologic Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA.
Background And Objective: A standard of care for muscle-invasive bladder cancer (MIBC) is cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC). Given recent improvements in NAC and the morbidity associated with RC, bladder-sparing therapy has been investigated as a promising treatment for patients with MIBC who experience a complete clinical response (CCR) to systemic therapy. However, clinical staging is unreliable, making it challenging to determine ideal candidates for bladder-sparing therapy.
View Article and Find Full Text PDFBackground: Cannabis is increasingly used and debates about the legalisation of the recreational use of cannabis are ongoing. In this prospective, placebo-controlled study in healthy volunteers not regularly consuming cannabis, subjective psychotropic and somatic effects after a single dose of intravenous THC were assessed and quantified over 48 h.
Methods: Twenty-five healthy volunteers received a single IV bolus of THC and 6 received normal saline.
Update on Cancer-Associated Venous Thromboembolism in Children.
Hamostaseologie
December 2024
Department of Oncology, Hematology, Immunology, Stem Cell Transplantation and Somatic Gene Therapy, University Children's Hospital Zurich - Eleonore Foundation, Zurich, Switzerland.
Children with cancer have an increased risk for venous thromboembolic events (VTEs) compared to the healthy pediatric population. VTE rates in children with cancer vary among cancer types. Other VTE risk factors include central venous catheters and cancer therapies.
View Article and Find Full Text PDFBarriers and potential solutions for collaboration between primary and secondary care in patients with persistent somatic symptoms and functional disorders: A nominal group technique study.
Eur J Gen Pract
December 2024
Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, Netherlands.
Article Synopsis
- * A study involving 102 healthcare professionals used the nominal group technique to identify barriers to collaboration and potential solutions, resulting in a list of key challenges and solutions.
- * Major barriers included communication issues, referral quality, and time constraints, while effective solutions suggested involved improved electronic consultations and consistent terminology usage.
Fetal alcohol spectrum disorders: where we have come from, trends, and future directions.
Minerva Pediatr (Torino)
December 2024
University of Salford, Salford, UK -
Fetal alcohol spectrum disorder (FASD) refers to a range of conditions caused by prenatal exposure to alcohol. First described in the 1970s as fetal alcohol syndrome, continuing progress has been made in the understanding, recognition and treatment of what is now recognized to be a range of related neurodevelopmental disorders. FASD is common, especially in countries with higher levels of alcohol consumption such as those in Europe and North America, where the prevalence is estimated to be around 3%.
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