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The biochemical and histological analysis of subcutaneous calcitonin and intramedullary methylprednisolone on bone repair after bone marrow ablation: an experimental comparative study in rats.
J Exp Orthop
December 2017
Faculty of Medicine, Department of Orthopaedics and Traumatology, Baskent University, Ankara, Turkey.
Background: Although, glucocorticoid (GC) and calcitonin-induced changes in bone repair have been studied previously, the exact effects of these on fracture healing remain controversial. Hence, the purpose of this experimental study is to determine biochemical and histological effects of locally administrated GC and systemically administrated calcitonin on the kinetics of healing response after bone marrow ablation in rats.
Methods: After having undergone marrow ablation, a steroid-treated group of rats (n = 24) received a single dose of intramedullary methylprednisolone (2 mg/kg), a calcitonin-treated group (n = 24) received intermittently administrated subcutaneous salmon calcitonin (16 IU/kg), and a control group (n = 24) received intramedullary saline (25 μl).
Calcium channel blockers inhibit the hyperglycemic effect of calcitonin.
Bull Exp Biol Med
March 2012
Department of General Physiology, St. Petersburg State University, Russia.
We studied the effect of Russian preparation of porcine calcitonin (calcitrin, 1 U/100 g) and blockers of Ca(2+) channels nifedipine (1 mg/kg, blocker of chemosensitive Ca(2+) channels) and isoptin (5 mg/kg, blocker of voltage-dependent Ca(2+) channels) on glucose metabolism. Calcitonin produced a pronounced hyperglycemic effect in rats. A close negative correlation was found between glucose level and total calcium content.
View Article and Find Full Text PDFSolid gastric emptying mediated by the serotonin (5-HT)3 receptor in mice is a simple marker to predict emesis.
J Toxicol Sci
January 2011
Department of Comparative Pathophysiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
Nausea and emesis are often observed as side effects with many medicines and may lead to poor treatment compliance. In the present study, we aimed to establish simple methods for predicting nausea and/or emesis in mice, which do not vomit, using drugs and chemicals known to evoke nausea and/or emesis. The gastrointestinal transit test, the liquid gastric emptying by phenol red solution (Phenol red method) and the solid gastric emptying by resin beads (Beads method) were used and the effects of antispasmogenics (atropine, 0.
View Article and Find Full Text PDFThe birth of the osteoclast.
Ann N Y Acad Sci
March 2010
Department of Cellular Pathology, St. George's, University of London, London, UK.
Thirty-five years ago it had become clear that the osteoclast was not a bone cell but an immigrant into bone, derived from the hemopoietic system. Among hemopoietic cells, mononuclear phagocytes seemed the most likely precursors. However, for the progeny of wandering cells such as those to achieve nonrandom localization implies control by the local bone cells (cells of the osteoblastic lineage).
View Article and Find Full Text PDFAn immunohistochemical study of the antinociceptive effect of calcitonin in ovariectomized rats.
BMC Musculoskelet Disord
December 2008
Department of Orthopedic Surgery, Fukushima Medical University School of Medicine, 1-Hikarigaoka, Fukushima City, Fukushima, 960-1295, Japan.
Background: Calcitonin is used as a treatment to reduce the blood calcium concentration in hypercalcemia and to improve bone mass in osteoporosis. An analgesic effect of calcitonin has been observed and reported in clinical situations. Ovariectomized (OVX) rats exhibit the same hormonal changes as observed in humans with osteoporosis and are an animal model of postmenopausal osteoporosis.
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