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Malakoplakia Associated with Diarrhoea and Colonic Lesions After Rituximab Treatment.
Eur J Case Rep Intern Med
December 2024
Gastroenterology Department, Adan Hospital Kuwait, Hadiya, Kuwait.
Unlabelled: Malakoplakia is a rare granulomatous condition that occurs due to defective lysosomal digestion during phagocytosis and can mimic inflammatory bowel disease (IBD) or malignancies, particularly in immunosuppressed patients. We report the case of a 62-year-old male with IgG4-related orbitopathy, who developed persistent diarrhoea and colonic lesions 6 weeks after receiving rituximab therapy for nephrotic syndrome secondary to membranoproliferative glomerulonephritis. Colonoscopy revealed pancolitis with mucosal granularity, loss of vascular pattern, and small nodules, raising initial suspicion for IBD.
View Article and Find Full Text PDFCOLONIC MALAKOPLAKIA.
J Ayub Med Coll Abbottabad
November 2024
Jinnah Postgraduate Medical Centre, Karachi-Pakistan.
This case report is of a 10-year-old female who presented with complaints of blood in her stool and colicky abdominal pain for the last 1.5 years. Biopsy samples from the rectum and left-sided colon were taken during a colonoscopy, revealing numerous histiocytes having calcified bodies (Michaelis-Gutmann bodies).
View Article and Find Full Text PDFMalakoplakia: A rare cause of hematochezia in pediatric patients.
JPGN Rep
August 2024
Division of Gastroenterology, Hepatology, & Nutrition, Ann & Robert H. Lurie Children's Hospital of Chicago Northwestern University Feinberg School of Medicine Chicago Illinois USA.
Article Synopsis
- * The condition commonly affects the urinary tract and gastrointestinal tract, particularly the colon and rectum, and is seldom seen in children.
- * Treatment involves using specific antibiotics that target macrophages and cholinergic agents to enhance the immune response, with a reported case in a pediatric leukemia patient highlighting its rarity.
Successful treatment of intestinal malakoplakia in a French Bulldog.
J Vet Med Sci
September 2024
North lab, Hokkaido, Japan.
Article Synopsis
- - Malakoplakia is a rare type of inflammation mainly seen in the urinary bladders of dogs, with only one previous case reported in the colon.
- - A 5-month-old spayed female French Bulldog was diagnosed with colonic malakoplakia after showing symptoms like chronic diarrhea and blood in feces, which did not improve with initial treatments.
- - The dog showed significant recovery after 8 months of treatment with enrofloxacin, with noticeable progress after just 2 months.
Colonic malakoplakia in a pediatric renal transplant recipient case report.
SAGE Open Med Case Rep
March 2024
Division of Pediatric Nephrology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Article Synopsis
- * A case report describes a 15-year-old male kidney transplant recipient who developed malakoplakia after experiencing recurrent diarrhea, confirmed through various tests and a colonoscopy.
- * The patient initially responded well to trimethoprim-sulfamethoxazole but faced a recurrence after 9 months, leading to a change in treatment to oral gentamicin, which resulted in remission.
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