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Identifying phase-separated structures remains challenging, and effective intervention methods are currently lacking. Here we screened for phase-separated proteins in breast tumour cells and identified forkhead (FKH) box protein M1 (FOXM1) as the most prominent candidate. Oncogenic FOXM1 underwent liquid-liquid phase separation (LLPS) with FKH consensus DNA element, and compartmentalized the transcription apparatus in the nucleus, thereby sustaining chromatin accessibility and super-enhancer landscapes crucial for tumour metastatic outgrowth.

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Soluble starch/zinc oxide nanocomposites could be promising candidates for eco-friendly antimicrobial, food packaging, and a wide range of other utilization. In order to find a new way for the preparation of this kind of nanocomposites, an efficient and energy-saving reaction for the synthesis of soluble starch/zinc oxide nanocomposites has been investigated. The reaction was implemented in a solid state at room temperature without post-reaction calcination.

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Perovskite nanocrystals (NCs) with their excellent optical and semiconductor properties have emerged as primary candidates for optoelectronic applications. While extensive research has been conducted on the 3D perovskite phase, the zero-dimensional (0D) form of this promising material in the NC format remains elusive. In this paper, a new synthesis strategy is proposed.

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Engineering Active Interfaces on the Surface of Porous Single-Crystalline TiO Monoliths for Enhanced Catalytic Activity and Stability.

Research (Wash D C)

January 2025

Key Laboratory of Design & Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China.

The engineering design and construction of active interfaces represents a promising approach amidst numerous initiatives aimed at augmenting catalytic activity. Herein, we present a novel approach to incorporate interconnected pores within bulk single crystals for the synthesis of macroscopic porous single-crystalline rutile titanium oxide (R-TiO). The porous single crystal (PSC) R-TiO couples a nanocrystalline framework as the solid phase with pores as the fluid phase within its structure, providing unique advantages in localized structure construction and in the field of catalysis.

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Removable dialkoxybenzyl linker for enhanced HPLC purification of peptide hydrazides.

Org Biomol Chem

January 2025

Department of Engineering, Graduate School of Integrated Science and Technology, Shizuoka University, 3-5-1 Johoku, Hamamatsu, Shizuoka 432-8561, Japan.

High-performance liquid chromatography (HPLC) plays a crucial role in purifying peptides and proteins and monitoring their reactions. Peptide hydrazides are widely employed intermediates in modern peptide/protein chemistry. However, they often exhibit peak tailing during HPLC purification and analysis.

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