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Navigating the Challenges of Cyclosporine as an Alternative to Rifampicin as an OATP1B Index Inhibitor.
Clin Pharmacol Ther
January 2025
Clinical Pharmacology, Pfizer R&D, Pfizer Inc, New York, New York, USA.
Rifampicin is a widely employed index inhibitor to assess the impact of organic anion transporting polypeptide 1B (OATP1B) inhibition on investigational drugs. The observation of nitrosamines in certain drug products, including rifampicin, has impacted the conduct of clinical drug-drug interaction (DDI) studies with rifampicin drug products. Cyclosporine is a recommended alternative to assess in vivo OATP1B activity; however, challenges exist in its use due to pharmacokinetic (PK) variability and non-selective inhibition of other drug disposition mechanisms.
View Article and Find Full Text PDFNovel Curvularia species causing disseminated phaeohyphomycosis in a dog.
Top Companion Anim Med
January 2025
Department of Specialty Medicine, Midwestern University, College of Veterinary Medicine, Glendale, AZ, USA.
Phaeohyphomycosis is an uncommon disease caused by dematiaceous fungi that is almost exclusively found in immunocompromised dogs. Here we describe the case of a dog treated with prednisone (1.1 mg/kg/day) and cyclosporine (11.
View Article and Find Full Text PDFRole of letermovir therapeutic drug monitoring for cytomegalovirus prophylaxis in allogeneic hematopoietic stem cell transplantation recipients: a prospective study.
Eur J Clin Microbiol Infect Dis
January 2025
Department of Pharmacy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.
Purpose: The role of therapeutic drug monitoring (TDM) in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients receiving letermovir has not yet been clarified. This study is to explore letermovir trough concentration (C) correlation with its clinical efficacy and adverse events, and factors affecting its plasma concentrations.
Methods: A prospective, non-interventional study was performed in allo-HSCT recipients receiving letermovir prophylaxis.
Risk Factors for Cytomegalovirus Infection after Haematopoietic Stem Cell Transplantation: A Meta-Analysis.
J Coll Physicians Surg Pak
November 2024
Department of Stem Cell Transplantation, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
Cytomegalovirus (CMV) infection is the most common viral infection after haematopoietic stem cell transplantation (HSCT). However, studies on related risk factors give different views without any clear conclusion. Therefore, the purpose of this study was to evaluate the risk variables of CMV infection after HSCT in order to provide recommendations for therapeutic treatment.
View Article and Find Full Text PDFProgression of cyclosporine A-blood levels in experimental cats receiving a high-dose treatment protocol.
Front Vet Sci
October 2024
Small Animal Clinic, University of Veterinary Medicine Hannover, Foundation, Hannover, Germany.
Background: Cyclosporine A (CsA) is used as a steroid-sparing or alternative immunosuppressing agent in cats with various immune-mediated diseases such as immune-mediated hemolytic anemia. Daily treatment dosages of 5-20 mg/kg have been described. Interindividual variations in CsA blood levels are known to occur.
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