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Objectives: To explore the landscape of BRCA1/2 mutations in gastric cancer patients.
Methods: Next-generation sequencing (NGS), Sanger sequencing, reverse transcription quantitative polymerase chain reaction (RT-qPCR), Immunohistochemistry, The Cancer Genome Atlas (TCGA), gnomAD, and DAVID.
Results: With 95% of bases boasting a phred score surpassing 30 and a minimum coverage depth of 500X, our NGS approach ensures high-quality data acquisition.
Sphingolipid long chain bases as mediators of cell death in olive fruit abscission.
Physiol Plant
January 2025
Laboratory of Plant Physiology, Universidad de Extremadura, Badajoz, Spain.
Plant sphingolipids are lipophilic membrane components essential for different cellular functions but they also act as signaling molecules in various aspects of plant development. However, the interaction between plant sphingolipids and abscission remains largely uncharacterized. Here, the possible role of sphingolipids in regulating fruit abscission was examined in the abscission zone (AZ) of olive fruit.
View Article and Find Full Text PDFA Guide to Breast Cancer Research: An Introduction.
Adv Exp Med Biol
January 2025
Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
"A Guide to Breast Cancer Research: From Cells and Molecular Mechanisms to Therapy" is designed as a comprehensive reference for early career investigators and postgraduate students. This book aims to provide a broad overview of contemporary breast cancer research. It covers key areas including development and cancer, metastasis and immunology, subtypes, signalling, therapy, and resistance.
View Article and Find Full Text PDFComputational Approaches for Multitarget Drug Design in Alzheimer's Disease: A Comprehensive Review.
Curr Med Chem
January 2025
Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca, Sidi Othman, Box 7955, Casablanca, Morocco.
Alzheimer's disease (AD) is a chronic and progressive neurodegenerative brain disorder, primarily affecting the elderly. Its socio-economic impact and mortality rate are alarming, necessitating innovative approaches to drug discovery. Unlike single-target diseases, Alzheimer's multifactorial nature makes single-target approaches less effective.
View Article and Find Full Text PDFMotion analysis of and experimental research on a magnetic and elastic coupling oscillation system.
Heliyon
July 2024
School of Physics, Changchun University of Science and Technology, Changchun, 130022, China.
To analyze the motion laws of a magnetic and elastic coupling system under the influence of various factors, this paper proposes a magnetic coupling pendulum based on spring pieces and magnets-a magnetic-mechanical oscillator. By fixing spring pieces onto two non-magnetic bases and attaching magnets to their upper ends, which repel each other, the potential energy during oscillation is expanded using Fourier series. Subsequently, Lagrange equations are solved to study the effects of the first two terms of potential energy.
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