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Alzheimers Dement
December 2024
Yale University School of Medicine, New Haven, CT, USA.
Background: Kv1.3 channels are promising therapeutic targets to modulate neuroinflammatory responses in neurodegenerative disease including Alzheimer's disease (AD). Although the ability of Kv1.
View Article and Find Full Text PDFAssessment of the efficacy of on-demand tegoprazan therapy in gastroesophageal reflux disease through a randomized controlled trial.
Sci Rep
January 2025
Department of Gastroenterology, CHA Ilsan Medical Center, Ilsan, Republic of Korea.
In patients with gastroesophageal reflux disease (GERD) whose symptoms improve with acid-suppression therapy, on-demand treatment could constitute maintenance therapy. This study investigated the comparative efficacy and safety of on-demand tegoprazan and proton-pump inhibitor (PPI) therapy in GERD. From six university hospitals in the Daejeon-Chungcheong region, we enrolled patients with GERD who had experienced symptomatic improvement with acid-suppressive therapy and, using a randomization table, randomly allocated these participants to two groups: to receive either tegoprazan 50 mg + esomeprazole placebo or tegoprazan placebo + esomeprazole 20 mg, respectively.
View Article and Find Full Text PDFThe modulation of calcium and chloride channels induces cardiomyocytes from human pluripotent stem cells.
Int J Biol Sci
January 2025
Faculty of Health Sciences, University of Macau, Taipa, Macau.
Ion channels play a crucial role in cardiac functions, and their activities exhibit dynamic changes during heart development. However, the precise function of ion channels in human heart development remains elusive. In this study, we utilized human embryonic stem cells (hESCs) as a model to mimic the process of human embryonic heart development.
View Article and Find Full Text PDFSlick potassium channels limit TRPM3-mediated activation of sensory neurons.
Front Pharmacol
December 2024
Institute of Pharmacology and Clinical Pharmacy, Goethe University Frankfurt, Frankfurt, Germany.
Heat sensation is mediated by specialized heat-sensitive neurons in the somatosensory system that innervates the skin. Previous studies revealed that noxious heat sensation is controlled by the sodium (Na)-activated potassium (K) channel Slick (Kcnt2), which is highly expressed in nociceptive Aδ-fibers. However, the mechanism by which Slick modulates heat sensation is poorly understood.
View Article and Find Full Text PDFFacile synthesis of g-CN@Sulfated titania nanocomposites with enhancement visible-light degradation of dyes and antibiotics: Mechanistic and DFT studies.
J Environ Manage
December 2024
Chemistry Department, Faculty of Science, Benha University, Benha, 13518, Egypt.
The photocatalytic efficiency of TiO has been opposed by the fast recombination speed of photogenerated carriers. Here, g-CN -modified sulfate-built-in TiO quantum dots (ST-QDs) were successfully created using a simple ultrasonication-thermal procedure. g-CN-enrapped ST QDs with a 10 nm size were revealed by the characterization results.
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