Dan Waldorf was a research sociologist who worked in the field of drug use and abuse for 27 years. Most of that time was either in San Francisco or New York City. He wrote two books, three monographs, and 38 articles on the subject--with this being his final article. Fate intervened because this article is autobiographical. Dan's work and his life were intertwined in ways that provided unique insights into drugs and addict lifestyles. The focus of much of his work was "to attack and demolish myths about drug users and heroin addicts" (his words). Dan's legacy is broad ranging, including historical accounts of morphine users and the federal response to close down morphine clinics in the first quarter of this century; he made snowball sampling methods respectable; he saw rationality in the actions of heroin addicts and demonstrated this drug was not all-consuming; and he performed a similar service for cocaine. He struggled to maintain his career as a drug researcher, often without the support of federal monies. As recently as two years before his death, he traveled around the country to document the history of underground needle exchange programs that were developing--using his retirement savings. This article documents his many scientific contributions to our understanding of drug use in general, and the interface of drug use and crime in particular. Dan led a simple yet ever so rich life because he never shied away from telling the truth, and the wisdom of his vision helped so many others of us to see. That is his greatest legacy--and his gift.
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http://dx.doi.org/10.3109/10826089809059328 | DOI Listing |
J Oncol Pharm Pract
January 2025
Department of Pharmacy, Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, Pakistan.
Study Objective: Complex pharmacotherapy in cancer patients increases the likelihood of drug-drug interactions (DDIs). Pharmacists play a critical role in the identification and management of DDIs. The aim of present study was to evaluate the role of pharmacist in identifying antifungal drug interactions in cancer patients and providing relevant recommendations.
View Article and Find Full Text PDFBMC Pharmacol Toxicol
January 2025
Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Objective: Cyclin-dependent kinase (CDK)-4/6 inhibitors have significantly improved outcomes in several cancers but can also induce various organ system toxicities, including musculoskeletal disorders. This study aimed to comprehensively characterize the musculoskeletal adverse events (MSAEs) associated with CDK4/6 inhibitors based on real-world data.
Methods: Reports of MSAEs linked to CDK4/6 inhibitors from the first quarter (Q1) of 2015 and 2023 Q4 were extracted from the FAERS.
J Cardiothorac Surg
January 2025
Semmelweis University Heart and Vascular Centre, Budapest, 1122, Hungary.
Background: Aortic dissection occurs rarely during pregnancy but carries a significantly high vital risk for both the mother and the fetus. Early diagnosis and treatment are critical for a successful outcome.
Case Presentation: A 32-year-old pregnant woman at 31 weeks of gestation began experiencing shortness of breath, chest pain, and palpitations, which were attributed to an anxiety disorder she had been previously diagnosed with.
J Cheminform
January 2025
School of Systems Biomedical Science, Soongsil University, 369 Sangdo-ro, Dongjak-gu, 06978, Seoul, Republic of Korea.
G protein-coupled receptors (GPCRs) play vital roles in various physiological processes, making them attractive drug discovery targets. Meanwhile, deep learning techniques have revolutionized drug discovery by facilitating efficient tools for expediting the identification and optimization of ligands. However, existing models for the GPCRs often focus on single-target or a small subset of GPCRs or employ binary classification, constraining their applicability for high throughput virtual screening.
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