AI Article Synopsis
- - The study tested the effects of a cannabinoid receptor blocker, SR 141716, on food intake and body weight in non-obese Wistar rats.
- - Administering SR 141716 led to a dose-dependent decrease in both food consumption and body weight, but tolerance to its appetite-suppressing effects developed within 5 days.
- - Despite the tolerance effect, the rats still maintained lower body weight compared to control groups throughout the 14-day study, indicating that cannabinoid receptors play a role in appetite and weight regulation.
Article Abstract
The effect of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight was assessed in adult, non-obese Wistar rats. The daily administration of SR 141716 (2.5 and 10 mg/kg; i.p.) reduced dose-dependently both food intake and body weight. Tolerance to the anorectic effect developed within 5 days; in contrast, body weight in SR 141716-treated rats remained markedly below that of vehicle-treated rats throughout the entire treatment period (14 days). The results suggest that brain cannabinoid receptors are involved in the regulation of appetite and body weight.
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| http://dx.doi.org/10.1016/s0024-3205(98)00322-1 | DOI Listing |
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