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Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques.
Pharmaceutics
January 2025
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Nanosuspensions (NS), with their submicron particle sizes and unique physicochemical properties, provide a versatile solution for enhancing the administration of medications that are not highly soluble in water or lipids. This review highlights recent advancements, future prospects, and challenges in NS-based drug delivery, particularly for oral, ocular, transdermal, pulmonary, and parenteral routes. The conversion of oral NS into powders, pellets, granules, tablets, and capsules, and their incorporation into film dosage forms to address stability concerns is thoroughly reviewed.
View Article and Find Full Text PDFPGM3 insufficiency: a glycosylation disorder causing a notable T cell defect.
Front Immunol
January 2025
Institute for Immunodeficiency, Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Background: Hypomorphic mutations in the () gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy. The exact etiology of this condition remains unclear.
View Article and Find Full Text PDFEffects of Educational Interventions Designed to Develop Physical Therapist Learners' Clinical Reasoning: A Systematic Review.
Phys Ther
December 2024
Northwell, New Hyde Park, NY, United States.
Objective: The objective of this systematic review was to investigate the effects of educational interventions designed to develop physical therapist learners' clinical reasoning across the full continuum of professional development.
Data Sources: A systematic search was conducted of 6 databases, the entire Journal of Physical Therapy Education collection, and the reference lists of included articles through March 2022.
Study Selection: English-language primary relevant research studies of all research designs were included while grey literature was excluded.
Investigating Oil Entrance from Hendijan Oil Field in the Northwest of the Persian Gulf Using Chemical Fingerprinting.
Arch Environ Contam Toxicol
December 2024
School of Engineering and Architecture, Department of Civil, Chemical, Environmental and Materials Engineering, University of Bologna, Terracini 28, 40131, Bologna, Italy.
Concerning the entrance of oil into the Persian Gulf due to the presence of oil fields in this ecosystem, a wide investigation was carried out in 2017 to evaluate the hydrocarbons source identification and chemical fingerprinting. To this end, surface sediments were collected from the Persian Gulf. In the laboratory, compounds (n-alkanes, PAHs, hopane and sterane) were then extracted with a Soxhlet system and two steps of chromatographic columns and analyzed using a GC-MS instrument.
View Article and Find Full Text PDFRandomized controlled trial parallel-group on optimizing community pharmacist's care for the elderly: The influence of WhatsApp-Email delivered clinical case scenarios.
PLoS One
October 2024
Department of Basic Medical Sciences, College of Medicine, Dar Al Uloom University, Riyadh, KSA.
Background: Drug-related problems (DRPs) significantly threaten the safety of the elderly. In order to improve pharmacists' ability to minimize these events, novel educational interventions that consider the current challenges in clinical practice are crucial.
Objectives: The primary objective is to assess the impact of two unique educational interventions on pharmacists' ability to identify DRPs.
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