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Impact of monosodium glutamate-induced obesity on learning, memory, and DNA damage: sex-based comparative study in rats.
Physiol Behav
January 2025
Department of Internal Medicine, Faculty of Medicine, Pamukkale University, Denizli, Türkiye.
Obesity is a global health crisis linked to numerous adverse outcomes including cardiovascular disease, type 2 diabetes, cancer and cognitive decline. This study investigated the sex-specific effects of monosodium glutamate (MSG)-induced obesity on learning, memory, anxiety-like behavior, oxidative stress, and genotoxicity in rats. In 32 neonatal Wistar albino rats, subcutaneous MSG injections were administered to induce obesity.
View Article and Find Full Text PDFPsychosocial interventions for children and adolescents with adverse childhood experiences: A systematic review and meta-analysis.
Child Abuse Negl
January 2025
School of Nursing & Healthcare Leadership, University of Washington, Tacoma, WA, United States.
Backgrounds: Exposure to adverse childhood experiences (ACEs) is associated with adverse neurobiological, developmental, cognitive, behavioral, psychological, and social consequences among children and adolescents. Psychosocial interventions hold promise for mitigating the negative impacts of ACEs, but there is a lack of updated and comprehensive evidence summarizing their effects qualitatively and quantitatively.
Aims: We performed a systematic review and meta-analysis of existing evidence on the effectiveness of psychosocial interventions on children's outcomes, including internalizing and externalizing problems.
Cancer-associated thrombosis: what is new?
Curr Opin Oncol
January 2025
Paris Cité University, Assistance-Publique-Hôpitaux de Paris (AP-HP), Service de Médecine Interne, Hôpital Louis-Mourier, Inserm, Paris Cardiovascular Research Center, Team « Endotheliopathy and Hemostasis Disorders », Paris, France.
Purpose Of Review: The life expectancy of patients suffering from thrombosis associated with cancer has improved significantly, making them a chronic disease. Patients with thrombosis and cancer are fragile. Treated with anticoagulants, they remain at risk of complications.
View Article and Find Full Text PDFImpact of time in tight range on all-cause and cardiovascular mortality in type 2 diabetes: A prospective cohort study.
Diabetes Obes Metab
January 2025
Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Aims: Currently, there is a lack of evidence regarding time in tight range (TITR) and long-term adverse outcomes. We aimed to investigate the association between TITR and the risk of all-cause and cardiovascular mortality among patients with type 2 diabetes.
Materials And Methods: A total of 6061 patients with type 2 diabetes were prospectively recruited in a single centre.
Assessment of hemodynamic disturbances and impaired ventricular filling in asymptomatic fontan patients: A 4D flow CMR study.
Eur J Radiol Open
June 2025
Department of Radiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, 1678 Dong Fang Road, Shanghai 200127, PR China.
Background: The Fontan procedure is a surgical intervention designed for patients with single ventricle physiology, wherein the systemic venous return is redirected into the pulmonary circulation, thereby facilitating passive pulmonary blood flow without the assistance of ventricular propulsion. Consequently, long-term follow-up of individuals who have undergone the asymptomatic Fontan procedure is essential.
Objectives: The aims of this investigation were to: 1) examine the impact of flow components and kinetic energy (KE) parameters on hemodynamic disturbances in asymptomatic Fontan patients and control group; 2) Assess left ventricular diastolic dysfunction through the analysis of 4D flow parameters across different Fontan sub-groups; 3) Compare intracardiac flow parameters among Fontan sub-groups based on morphological features of the left ventricle (LV) and right ventricle (RV).
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