Interleukin-6-deficient (IL-6(-/-)) knockout mice had significantly increased Chlamydia trachomatis levels in lung tissue and increased mortality compared to B6129F2/J controls early after intranasal infection. Gamma interferon production and chlamydia-specific antibody levels were consistent with a decreased but reversible Th1-like response in IL-6(-/-) mice. IL-6 is needed for an optimal early host response to this infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC108560 | PMC |
| http://dx.doi.org/10.1128/IAI.66.9.4564-4567.1998 | DOI Listing |
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