Collagenous gastritis is a rare histopathological disorder of unknown origin, characterized by a subepithelial collagen deposit greater than 10 microm thick, associated with an inflammatory infiltrate of the gastric mucosa. This report describes a second pediatric case of collagenous gastritis, revealed by severe anemia caused by gastric bleeding, as was the first case. Unlike the adult cases of collagenous gastritis, lesions were limited to the stomach, and remained unchanged on six series of biopsies taken during a 30 month follow-up, despite treatment with omeprazole, sucralfate and corticosteroids. An immunohistochemical study showed signs of local immune activation on all biopsy specimens, including overexpression of HLA-DR by epithelial cells, increased numbers of CD3+ intraepithelial lymphocytes, and CD25+ cells in the lamina propria. Although the cause of the disease remains unclear, our findings suggest that the histopathological lesions of collagenous gastritis may result from a local immune process.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0046-8177(98)90461-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Recent biomedical research has shown the unusual, multisystem effects of coronavirus disease 2019 in humans. One specific sequela of a primary severe acute respiratory syndrome coronavirus 2 infection is the reactivation of latent viruses in various tissues, such as Epstein-Barr virus. Epstein-Barr virus has been identified in many inflammatory gastrointestinal lesions, such as microscopic gastritides and colitides.
View Article and Find Full Text PDFA case description of collagenous gastritis concurrent with collagenous colitis: visible endoscopic changes.
Quant Imaging Med Surg
December 2024
Endoscopy Unit, The Second University Clinic, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
Pediatric Collagenous Gastroduodenitis: A Rare Cause of Iron-Deficiency Anemia.
Cureus
November 2024
Pediatric Gastroenterology, University of South Florida Morsani College of Medicine, Tampa, USA.
Collagenous gastroenteritidesare rare disorders of unknown etiology diagnosed histologically by marked subepithelial deposition of collagen bands thicker than 10µm in the lamina propria with a mononuclear inflammatory infiltrate. Collagenous gastritis (CG) is divided into two phenotypes - pediatric-onset and adult-onset. Up until recently, pediatric-onset CG was thought to be confined to the stomach presenting with abdominal pain and anemia with limited involvement of the colon.
View Article and Find Full Text PDFOlmesartan-induced collagenous gastritis.
Lancet
October 2024
Department of Gastroenterology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Collagenous and lymphocytic gastritis in pediatric patients. A single-center experience observing an increase in diagnosis in recent years.
Scand J Gastroenterol
October 2024
Department of Pediatrics, Kaplan Medical Center, Rehovot, Israel.
Article Synopsis
- Collagenous gastritis (CG) and Lymphocytic gastritis (LG) are uncommon forms of gastritis characterized by specific cellular changes, and this study aimed to analyze their prevalence and features in children over a 23-year period.
- In a review of 31 pediatric cases, CG was found in 11 patients (35.5%), while LG was identified in 20 patients (64.5%), most of whom presented with gastrointestinal symptoms and iron deficiency anemia.
- Treatment typically involved iron supplements, proton pump inhibitors, and dietary changes, with most patients showing improvement in hemoglobin levels, although some required ongoing treatment and a follow-up endoscopy showed no significant histopathological changes
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!