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PLGA-Nano-Encapsulated Disulfiram Inhibits Cancer Stem Cells and Targets Non-Small Cell Lung Cancer In Vitro and In Vivo.
Biomolecules
December 2024
Faculty of Science and Engineering, University of Wolverhampton, Wolverhampton WV1 1LY, UK.
Cancer stem cells (CSCs) play a key role in non-small cell lung cancer (NSCLC) chemoresistance and metastasis. In this study, we used two NSCLC cell lines to investigate the regulating effect of hypoxia in the induction and maintenance of CSC traits. Our study demonstrated hypoxia-induced stemness and chemoresistance at levels comparable to those in typical CSC sphere culture.
View Article and Find Full Text PDFEfficacy of sodium oxybate plus disulfiram for the maintenance of alcohol abstinence in treatment-resistant patients with alcohol use disorder: a multicentre retrospective study.
Ann Ist Super Sanita
December 2024
Dipartimento di Medicina Traslazionale e per la Romagna, Università di Ferrara, Ferrara, Italy.
Introduction: Disulfiram (DF), acamprosate, naltrexone, baclofen and sodium oxybate (SO) are currently the medications approved for the treatment of alcohol use disorder (AUD). In this context, combined pharmacological interventions and sex differences are an interesting area in the treatment of non-responder AUD patients.
Aim: To evaluate the efficacy of SO in combination with DF in maintaining alcohol abstinence in patients with AUD who failed to achieve abstinence either with SO or DF alone.
Disulfiram-containing polymeric nanocapsules with anticancer activity for cancer treatment.
Int J Pharm
January 2025
Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, MA 02115, USA; Supervisor of Shared Research Facilities, School of Pharmacy and Department of Pharmaceutical Sciences, Northeastern University, USA; Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA. Electronic address:
Article Synopsis
- Disulfiram, a medication previously used for alcohol addiction, is being studied as a cancer treatment due to its ability to inhibit cancer cell growth and enhance the effectiveness of chemotherapy and radiation.
- The drug induces apoptosis (cell death) in cancer cells and can be effective against various types of cancer, including breast and prostate cancer.
- Researchers are focusing on new delivery systems, like polycaprolactone-based nanocapsules, which improve the drug's stability and cytotoxicity, suggesting a promising avenue for more effective and safer cancer treatments.
Regaining control over alcohol intake but not abstinence on disulfiram medication, as a harm reduction approach: 2 case reports.
Addict Sci Clin Pract
December 2024
Department of Psychiatry and Psychotherapy, Carl Gustav Carus Faculty of Medicine, Carl Gustav Carus University Hospital Dresden, Dresden University of Technology, Dresden, Germany.
Background: Alcohol use disorder (AUD) poses severe health risks, yet many affected individuals opt out of complete abstinence. Therefore, harm reduction strategies have become more prominent in treatment guidelines for AUD. Our two case reports illustrate how disulfiram, initially intended to enforce abstinence, was repurposed to support reduced drinking.
View Article and Find Full Text PDFCombined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells.
Mol Cancer
October 2024
Institute of Hematology, School of Medicine, Jinan University, Guangzhou, 510632, China.
Article Synopsis
- BCR-ABL+ leukemia faces significant challenges like drug resistance and the survival of leukemic stem cells (LSCs), despite progress with tyrosine kinase inhibitors (TKIs).
- In this study, Disulfiram (DSF), an FDA-approved drug for alcohol dependence, is shown to induce ferroptosis in resistant BCR-ABL+ cells and LSCs when combined with TKIs, leading to enhanced effectiveness in treatment.
- The research highlights DSF's mechanisms, such as degrading GPX4, increasing lipid peroxidation, and modulating iron metabolism, which collectively help overcome drug resistance and target leukemic cells more effectively.
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